Depression
Methylation, copper balance, inflammation, nutrients, hormones and other contributors.
Explore Depression →Mental Health Conditions & Biochemical Causes
Depression, anxiety, ADHD, OCD, autism, insomnia, bipolar disorder and cognitive decline can share underlying biochemical contributors. Explore each condition, then look deeper at methylation, copper and zinc balance, mitochondrial function, oxidative stress, inflammation, gut health, hormones and toxic burden.
Browse by Condition
Mental Health & Neurodevelopmental Conditions
Start with the diagnosis or symptom pattern most relevant to you. Each section explores possible biochemical contributors, testing and treatment considerations.
Anxiety & Panic
Copper overload, pyroluria, methylation, hormones, stress response and nutrient factors.
Explore Anxiety →ADHD
Dopamine regulation, methylation, zinc, iron, sleep, nutrition and medication response.
Explore ADHD →Autism & Development
Methylation, oxidative stress, folate receptor antibodies, immune, gut and nutrient factors.
Explore Autism →OCD
Undermethylation, neurotransmitter regulation, oxidative stress and treatment response.
Explore OCD →Bipolar Disorder
Sleep, mitochondrial function, inflammation, oxidative stress and biochemical contributors.
Explore Bipolar Disorder →Schizophrenia & Psychosis
Methylation, oxidative stress, copper-zinc balance, nutrition, sleep and stabilization.
Explore Schizophrenia →Insomnia
Methylation, copper, cortisol, hormones, blood sugar, inflammation and medication effects.
Explore Insomnia →Dementia & Cognitive Decline
Mitochondria, methylation, inflammation, vascular risk, nutrients, hormones and toxic burden.
Explore Cognitive Decline →
Look Deeper
Biochemical & Functional Contributors
These systems cross diagnostic boundaries. Problems in one or more may influence mood, cognition, sleep, behavior, energy and response to treatment.
Methylation Function
SAM, SAH, histamine, homocysteine and methylation efficiency.
Explore Methylation →Mitochondrial Function
ATP production, cellular energy, oxidative resilience, fatigue and methylation demand.
Explore Mitochondria →Oxidative Stress
Antioxidant defenses, cellular injury, mitochondrial stress and inflammation.
Explore Oxidative Stress →Gut Health & Dysbiosis
Microbiome balance, digestion, nutrient absorption and intestinal inflammation.
Explore Gut Health →Inflammation & Immunity
Immune activation and inflammatory signaling affecting brain and metabolic function.
Explore Inflammation →Histamine & Mast Cells
Histamine metabolism, allergy, mast-cell activity, sleep, anxiety and gut symptoms.
Explore Histamine →Hormones & Metabolism
Thyroid, adrenal and sex hormones, glucose regulation and metabolic health.
Explore Hormones →Kidney & Liver Function
Clearance, buffering, detoxification and metabolic influences on methylation.
Explore Kidney & Liver →Toxic Burden
Environmental exposures, metals, oxidative injury and interference with methylation.
Explore Toxic Burden →Biochemical Patterns That Cross Diagnoses
The Walsh Approach evaluates biochemical patterns rather than assuming that everyone with the same diagnosis has the same underlying chemistry. Several patterns may occur together.
Undermethylation
Methylation and neurotransmitter-regulation pattern often associated with characteristic symptoms and traits.
Overmethylation
A different biochemical and symptom pattern with different nutrient and medication considerations.
Copper Overload
Evaluated through copper, ceruloplasmin and zinc together with symptoms and history.
Pyroluria
A stress-sensitive pattern associated with urinary pyrroles and zinc/B6 requirements.
Toxic Burden
Environmental and metabolic stress may contribute to oxidative stress and impaired methylation.
Undermethylation can be evaluated more deeply.
Plasma methylation testing can assess SAM, SAH, methionine, homocysteine and related pathways. Expanded Epstein Epigenetic assessment examines additional drivers that may contribute to persistent undermethylation.
Plasma methylation testing can assess SAM, SAH, methionine, homocysteine and related pathways. Expanded Epstein Epigenetic assessment examines additional drivers that may contribute to persistent undermethylation.
From Symptoms to Measurable Biochemistry
Laboratory testing does not replace a psychiatric or medical diagnosis. Its role is to identify measurable factors that may affect neurotransmitter regulation, methylation, inflammation, cellular energy and nutrient needs.
Testing may include the Comprehensive Biotype Panel, focused copper, zinc or methylation testing, plasma SAM/SAH assessment, mitochondrial and oxidative-stress testing, gut testing, hormones and other targeted studies when clinically appropriate.