Men’s Comprehensive Hormone and Metabolic Health Panel

Testosterone and Androgen Status (Testosterone, Free Testosterone, SHBG, DHT)

This section evaluates overall androgen production, androgen availability, and androgen conversion patterns. Testosterone and free testosterone help assess libido, motivation, muscle maintenance, exercise recovery, cognitive performance, vitality, and healthy aging. SHBG is included to determine how much testosterone is biologically available to tissues versus tightly bound and inactive. Dihydrotestosterone (DHT), the most potent androgen derived from testosterone, helps evaluate androgen conversion patterns that may influence hair loss, prostate enlargement, libido, sexual performance, oily skin, and androgen sensitivity.

Pituitary and Gonadal Signaling (LH, FSH, Prolactin)

LH and FSH help evaluate pituitary signaling to the testes and may help distinguish primary testicular dysfunction from pituitary or hypothalamic suppression patterns. Elevated prolactin may suppress normal testosterone production and interfere with pituitary signaling, potentially contributing to low libido, erectile dysfunction, fatigue, nipple tenderness, infertility, or endocrine imbalance.

Estrogen Balance (Estradiol)

Estradiol testing evaluates estrogen balance in men. Elevated estradiol may contribute to nipple tenderness, fluid retention, increased abdominal fat, mood changes, reduced libido, or difficulty optimizing testosterone levels. Low estradiol may also contribute to reduced libido, joint discomfort, low mood, or cognitive changes. Estradiol is an important balancing hormone that influences overall endocrine function in men.

Thyroid and Metabolic Regulation (TSH, Free T4, Reverse T3)

This section evaluates thyroid regulation and thyroid hormone availability, which strongly influence metabolism, energy production, mood, body composition, temperature regulation, hormonal balance, and overall vitality. Thyroid dysfunction may contribute to fatigue, low motivation, weight gain, low testosterone patterns, and elevated prolactin. Reverse T3 may help identify stress-related thyroid conversion patterns where active thyroid hormone availability is reduced despite standard thyroid testing appearing “normal.”

Adrenal and Stress Response (Cortisol AM, DHEA-S)

Cortisol and DHEA-S provide insight into adrenal reserve and stress-axis regulation. These markers may help evaluate chronic stress physiology, burnout patterns, fatigue, poor recovery, reduced stress tolerance, sleep disruption, metabolic slowdown, and age-related hormonal decline. DHEA-S also functions as an adrenal androgen precursor and may reflect overall resilience and anabolic reserve.

Neurosteroid and Adrenal Steroid Balance (Progesterone, 17-OH Progesterone)

Progesterone and 17-OH progesterone provide additional information regarding neurosteroid balance, adrenal steroid metabolism, and androgen synthesis pathways. While progesterone is often associated with female hormone physiology, it also plays important neurologic and endocrine roles in men and may influence sleep quality, emotional regulation, stress response, and estrogen modulation. 17-OH progesterone may provide additional insight into adrenal hormone conversion pathways and androgen metabolism.

Prostate and General Metabolic Health (PSA, CBC, Comprehensive Metabolic Panel)

PSA testing may help evaluate prostate health and establish a baseline prior to testosterone replacement therapy or hormone optimization. A complete blood count (CBC) and comprehensive metabolic panel (CMP) provide important information regarding hematologic status, liver function, kidney function, glucose regulation, electrolytes, hydration status, and overall metabolic health. These markers are useful both for general health assessment and for safely monitoring hormone-related therapies.