When histamine is not reliable as a marker of methylation, the Methylation Panel by Doctors Data is a good alternative test. Histamine may not be reliable when persons have been taking antihistamines or medications that have antihistaminergic effects. It is also not an ideal test for overmethylators, but the Methylation Panel is a very good test for confirming or identifying if someone is an undermethylator.
Normal metabolism of methionine is critical for cellular methylation of DNA, proteins and neurotransmitters. Aberrant methionine metabolism can occur in anyone at any age and can be associated with numerous health consequences including cardiovascular disease and cancer. The Methylation Profile provides a functional assessment of the phenotypic expression of common SNPs (MTHFR, MS, CBS) by evaluating the plasma levels of methionine, cysteine, SAM, SAH, homocysteine and cystathionine, and provides the important “methylation index,” a ratio of SAM to SAH.