When histamine is not reliable as a marker of methylation, the Methylation Panel by Doctors Data is a good alternative test. Histamine may not be reliable when persons have been taking antihistamines or medications that have antihistaminergic effects. It is also not an ideal test for overmethylators, but the Methylation Panel is a very good test for confirming or identifying if someone is an undermethylator.
Normal metabolism of methionine is critical for cellular methylation of DNA, proteins and neurotransmitters. Aberrant methionine metabolism can occur in anyone at any age and can be associated with numerous health consequences including cardiovascular disease and cancer. The Methylation Profile provides a functional assessment of the phenotypic expression of common SNPs (MTHFR, MS, CBS) by evaluating the plasma levels of methionine, cysteine, SAM, SAH, homocysteine and cystathionine, and provides the important “methylation index,” a ratio of SAM to SAH.
Methylation Profile; plasma
Normal metabolism of methionine is critical for cellular methylation of DNA, proteins and neurotransmitters. Aberrant methionine metabolism can occur in anyone at any age and can be associated with numerous health consequences including cardiovascular disease and cancer. The Methylation Profile provides a functional assessment of the phenotypic expression of common SNPs (MTHFR, MS, CBS) by evaluating the plasma levels of methionine, cysteine, SAM, SAH, homocysteine, and cystathionine. It also provides the important “methylation index”, a ratio of SAM to SAH.
Completion Time
5 to 7 days
Analytes
Analyte | CPT | |||
---|---|---|---|---|
Cystathionine, plasma | 82136 | |||
Cysteine, plasma | 82136 | |||
Methionine, plasma | 82136 | |||
S-adenosylhomocysteine; plasma | 82542 | |||
S-adenosylmethionine; plasma | 82542 | |||
SAM, SAH ratio | ||||
This test is useful for
- Autism
- Birth Defects
- Cancer
- Cardiovascular Disease
- Congenital Heart Disease
- Detoxification Impairment
- Down Syndrome
- General Health and Longevity
- Genetic Disorders
- Immune Dysfunction
- Neurodegenerative Diseases
- Nutritional Deficiencies
- Psychiatric Disorders
Detailed Information
- Abnormal neurotransmitter metabolism and psychiatric disorders such as schizophrenia and bipolar disorder
- Neurodegenerative diseases
- Autism
- Dysregulation of nitric acid homeostasis
- Oxidative stress
- Global under-methylation, synthesis and repair of DNA
- Immune dysregulation/autoimmunity
- Cancer
- Cardiovascular disease
- Congenital heart disease and birth defects
- Impaired endogenous detoxification processes
- Increased risk for Down’s syndrome
TEST DIETARY CONSIDERATION
This assay determines the plasma levels of methionine, cysteine, SAM, SAH, Hcy and cystathionine, and provides the important “methylation index,” a ratio of SAM to SAH. The blood specimen must be collected after an overnight fast (12 hours). For 48 hours prior to the collection, the patient must discontinue taking supplements containing methioinine, TMG, cysteine, folates, or SAMe.