Cognoscopy Panel #4 for Testing Leaky Gut Syndrome and Celiac Disease

This testing panel involves two key components to assess both intestinal permeability (leaky gut) and to screen for celiac disease.

1. Zonulin Protein (Serum) – Doctors Data:
   • Zonulin is a protein that regulates the permeability of tight junctions in the intestines. High levels of zonulin are associated with increased intestinal permeability, often referred to as “leaky gut,” which allows bacteria, toxins, and undigested food particles to enter the bloodstream. This can lead to immune activation and inflammation, contributing to various conditions, including autoimmune diseases.
   • The zonulin serum test is used to measure zonulin levels in the blood, providing a direct assessment of intestinal barrier function. Elevated levels of zonulin in serum can indicate gut permeability and potential for systemic immune activation.
2. Tissue Transglutaminase (tTG) IgA and IgG – LabCorp (164640):
   • These tests are used to screen for celiac disease, an autoimmune condition where the immune system reacts to gluten, a protein found in wheat, barley, and rye.
   • tTG IgA is the primary marker used to detect celiac disease, as most individuals with celiac have elevated levels of tTG IgA antibodies.
   • tTG IgG is typically ordered if there is suspicion of celiac disease in individuals with an IgA deficiency or if tTG IgA results are negative but symptoms still suggest celiac disease.

Comprehensive Testing Strategy:

• By combining the zonulin serum test from Doctors Data with the tTG IgA and IgG tests from LabCorp, you gain a comprehensive view of both intestinal permeability (which may be associated with “leaky gut”) and screen for celiac disease.
• Elevated zonulin levels suggest compromised intestinal barrier function, while elevated tTG antibodies (IgA or IgG) point to a possible autoimmune reaction to gluten, characteristic of celiac disease.