Improve Brain Function, Naturally

Diagnostic testing and medical consulting to identify and manage
biochemistry imbalances underlying mood and behavior disorders.

Are you fed up with the conventional approach to treating depression?

Most practitioners treat depression with prescription drugs. At Second Opinion Physician, we utilize nutritional supplements to manage depression and other mood disorders. The recommendations provided by our physician is based on the unique biochemical profile or "Biotype" of the person being treated. Learn more about biotypes and the various conditions associated with nutrient imbalances that most affect the brain.

Second Opinion Physician provides testing, consultations and follow up support

Lab tests are ordered through Second Opinion. Once a test panel or individual test has been selected, a lab requisition will be sent with the necessary forms to have blood drawn at a local Lab Corp. Urine specimen kit will be mailed for a pyrrole test. Labs may be ordered as panels or individually.


Our primary approach to treating depression is to first identify an individuals"Biotype." The blood and urine test results along with an online questionnaire will be compiled and reviewed by the Second Opinion Physician. When selecting a consultation with report, patients will receive a multi-page assessement with explanation of your Biotype and supplement plan. 


Following a nutritional  protocol, persons often wish to have their blood retested to monitor their progress. This can be done in order to identify if targets have been met or if it's time to decrease or discontinue any of the supplements.  The SOP Physician is available for by phone or email to discuss your individual need and or necessity for retesting.

Dr David Epstein, D.O. is is an functional medicine physician utilizing state of the art testing and nutritional therapies to treat mental disorders.

Is this test protocol right for you?


Contact us now for a free "pre-consultation" with the physician



Schedule a call

Please include phone and best time to call

dr epstein walsh practitioner

According to the research of Dr William Walsh, as many as 95%, of all persons who suffer with mood disorders, are likely to have a biochemical imbalance that will respond favorably to nutritional therapy. Our Physician, Dr David Epstein DO is available to discuss the test and process for determining what is the best course of action for your health issue.


While Second Opinion Physician is not directly affiliated with the Walsh Institute, our physician, Dr Epstein is trained in the protocol and utilizes this for diagnosing all patients with mood disorders.

William Walsh PhD. himself, has spent many years investigating biochemical imbalances associated with mood and behavior disorders. His analysis has included tens of thousands of persons suffering with mental health conditions including depression, anxiety, Autism, ADHD, biopolar disorder, schizophrenia, post partum depression and psychosis.

Links below are to his various publications and presentations. For a more indepth overview, his publications are listed on the Walsh Institute Website. 


How does the test and consultation process work?

Go to the Labs and Assessments page and select the test and consultation service you would like to receive. You will receive a link to complete and online questionnaire. You will then get a test form to take to Lab Corp and your urine kryptopyrrole test kit will come to you by mail. Once tests and the questionnaire are complete you will receive results. If a consultation and assessment are also ordered these will be sent via secure email and a time will be made available to talk with the physician as a follow-up to the report.

Do you use genetic tests to determine methylation status or biotypes?

Genetic tests are not used. The protocol taught by Dr Walsh utilizes histamine for determining methylation status and other biotypes are determined according the panel made available on this website.

What if I already have my lab results but just want an Assessment and supplement Plan?

Consultation and Assessments are available for persons who already have labs, as long as they were completed in the past 3-4 months. Consultation fee is a bit higher, due to the extra time involved. Sometimes tests may have to be repeated if they were drawn by a less reliable source or appear ambiguous. 

Can you bill my insurance?

Second Opinion Physician does not bill insurance at this time. However upon request a statement will be provided with CPT codes and fees spent for the labs and consultation. Sometimes insurance or private funds will apply this to your deductible or reimburse for the services.

What are the Biotypes of Depression?

The 5 Biotypes of Depression is a term developed by Dr Walsh of the Walsh Institute to describe the primary biochemical classifications of mood and behavior disorders. When a practitioner knows one's biotype, then a specific nutrient strategy can be applied to the treatment strategy. 

What are the key influences on brain function identified through the Walsh Panel?

The key underlying factors influencing one's mood and behavior are the 1) the epigenetic (methylation) influences upon neurotransmitter activity and, 2) nutrition and the ability for key biochemical processes to take place and, 3) oxidative stress, an important indicator of need for nutrient and lifestyle management.

How do I determine my "biotype"? 

Your biotype will be determined by the results of the labs. For a full set of the Walsh Biotype we recommend doing the Comprehensive Biotype Panel with Consultation. If you are just looking to determine if you have one or another Biotype imbalance, consider ordering one of the following. Overmethylation or Undermethylation biotypes are determined by a whole blood histamine test. Copper Overload requires copper, ceruloplasmin and zinc tests or the combo Copper Overload test panel. For kryptopyrroles order the Pyrrole Urine Test

What does the term "methylation" have to do with depression?

Methylation is a term that describes the status of DNA activity in the production of proteins, enzymes and immune globulins. Overmethylators tend to have an underactive DNA 'transcription' process, whereas undermethylators have an overactivity of cellular function. 

Why does the therapy have to be individualized for each person?

As an example, individuals with overmethylation and overmethylation can experience mood disorders. Overmethylators issues arise from overactive serotonin and dopamine activity, while undermethylators it is due to an under active neurotransmitter activity. Addressing this imbalance is a major consideration in nutrient therapy. This is why treatment must be individualized.

Is Second Opinion Physician affiliated with the Walsh Institute?

Second Opinion Physician is independent from the non-profit Walsh Research Institute.

Where can I purchase supplements?

You may purchase supplements from any reputable source. Dosages and ingredients are provided with Assessment reports. To simplify the process of purchasing supplements online Second Opinion Physician has set up a website offering the top professional brands. It is called Biotype Nutrients. Supplements are categorized according to one's "biotype", a classification system developed by Dr Walsh.

How do I know what test to order?

If you are interested in a complete Walsh Panel with interpretation and supplement recommendations by the SOP Doctor then you'll want to order the "Lab Panel - Comprehensive Biotype". Be sure to select option "Diagnostic Test with Consult and Detailed Report".

I've already had a Second Opinion Comprehensive Panel. What follow up test do I order?

The initial Comprehensive Biotype Panel includes tests that do not necessarily have to be repeated.  If any of the following labs were out of balance then you may wish to repeat in 3-6 months. This includes one or more of the individual biotype lab tests such as vitamin D, homocysteine, copper, ceruloplasmin and zinc. Histamine and pyrroles do not have to be repeated unless we are uncertain about the results due to test handling or concurrent use of medicines or supplements. If you would like support in Assessing these results, consider options