Lab Tests Online and Telemedicine Consulting

Second Opinion Physician is an online functional medicine practice that provides testing, assessments and nutritional plan for managing mood, cognition and behavior disorders, naturally.  Our focus is on testing and consultations utilizing the 'Walsh Protocol' and the 'Bredesen Approach.' 

Thanks to advances in the science of epigenetics, nutrition and functional medicine, managing depression and brain function, naturally, is more possible than ever before.

With advances in the science of nutrition, epigenetics and oxidative therapy, it is possible to determine one's unique biochemistry and address imbalances to better manage depression, memory loss and many other mood disorders.



Lab Testing, Questionnaire and Biotype Report

Second Opinion Physician serves individuals and practitioners with competitively priced lab testing and consultations. Dr Epstein is a Walsh Trained physician and works by telemedicine to coordinate labs, evaluate results and health histories and provide a detailed Report and Plan focusing on nutritional supplements, diet and lifestyle and home devices to improve patients condition.

Utilizing secure, HIPAA compoiant emails, data storage and communications for:

Lab Tests
Follow Ups

Labs may be ordered as panels or individually. This can be especially useful when looking to determine one Biotype at a time to save money or to rule out primary concerns.

  • For mood disorders and when seeking a nutrient protocol per the teachings of Dr William Walsh, PhD. we advise patients to start with the Walsh Panel or the Comprehensive Biotype Panel
  • If you have symptoms of elevated histamine and would like to determine your baseline or else get advise on a nutrient protocol, the Methylation Panel is a good place to start. This can be used to determine if symptoms are due to high or low serotonin and dopamine activity.
  • If you would like to know what influence oxidative stress may have on your anxiety or stress related issues, the Copper Overload Panel will provide useful necessary information to correct your levels of dopamine and norepinephrine with supplementation.
  • When testing for key markers identified by Dale Bredesen, MD, for Alzheimers, there are 5 Cognoscopy Panels to consider. The first id identical to the Walsh Panel, because many of they both recommend most, plus we've added Walsh's test for methylation and pyrroles.



Lab Testing and Customized Biotype Reports

Second Opinion offers other physicians a lab testing service and assessment support.

  • Doctors may order single items, or full panels on this website on behalf of their patients to expedite the testing and reporting process.
  • Busy practices benefit from an off-site expert to coordinate lab orders, questionnaires and reports for patients that would benefit from the Walsh Panel.
  • Lab Corp requisition forms and urine test kits will be sent directly to the patient or to your clinic.
  • Secure online questionnaire that highlights relevant findings and Biotype related symptoms.
  • Customized reports provided that include History, Labs, Assessment and Supplement Recommendations.
  • Second Opinion is seeking Affiliate Practitioners in every State. Our affiliates will receive patient referrals for management as well as our Doctor to Doctor Biotype Report services.

Second Opinion Physician was developed and is maintained by David Epstein, D.O.. He is a licensed osteopathic physician with a 35 year history of practicing functional medicine.

Dr David Epstein, D.O. has been practicing functional medicine as a licensed physician since 1987. His private practice was established in 1989 in Atlanta, Georgia. He was one of Georgia's first integrative medicine providers offering chelation therapy, IV H2O2, and vitamins and nutritional counseling. Today Dr Dave practices via telemedicine entirely, and focuses on the protocol taught by the Walsh Research Instutite.

According to the research of Dr William Walsh, who is not affiliated with Second Opinion Physician, as many as 95%, of all persons who suffer with mood disorders, are likely to have a biochemical imbalance that will respond favorably to nutritional therapy. Feel free to reach out at any time to discuss the test and process for determining what is the best course of action for your health issue. When we're not working up an Assessment, we're here to answer your questions.

dr epstein walsh practitioner

For questions about the protocol or testing process...

Contact Dr Dave for a free "pre consultation" with Dr. Dave.


Testing and Treatment Methods Utilized

William Walsh PhD Protocol  
Methylation, Nutrition, Oxidative Stress

Dr Walsh has studied the brain chemistry of persons with mood disorders for over 40 years. His research and book Nutrient Power is groundbreaking and very important in the prevention and natural treatment of many conditions associated with high and low levels of neurotransmitters:

Mood, Cognition and Behavior Disorders
Depression and Bipolar Disorder
Schizophrenia and Psychosis
Anxiety Disorders
Autism, ADHD and Oppositional Defiance


Biotype Determination
Optimal Methylation Support
Metal Overload Detox
Anti-Oxidant and Metallothionein
Nutrient Supplementation
Nutrients to Avoid

Dale Bredesen MD Approach
Cognoscopy Test Panel

Bredesen wrote the popoular book the End of Alzheimers; his approach addresses similar factors as Dr Walsh, plus other areas that he describes that lead to dimished brain health with aging.



Genetic Evaluation
Hormone Support
Inflammation Reduction
Oxidation Improvement
Digestion and Leaky Gut
Mold and Environmental Exposure



Second Opinion Physician is not directly affiliated with the Walsh Institute, however, I am fully trained in the protocol and very confident in the benefits of this approach for diagnosis and management of patients with mood disorders.

William Walsh PhD. himself, has spent many years investigating biochemical imbalances associated with mood and behavior disorders. His analysis has included tens of thousands of persons suffering with mental health conditions including depression, anxiety, Autism, ADHD, biopolar disorder, schizophrenia, post partum depression and psychosis.

Links below are to his various publications and presentations. For a more indepth overview, his publications are listed on the Walsh Institute Website.

Most Popular Tests

To suit your financial needs or key areas of interest, select from our Comprehensive Panels, Modified Panels and Single Item Tests. Consultations available with or without detailed reports.

Cognoscopy Alzheimer's Panel

Cognoscopy Lab Panel #1


Other Lab Panels

Hashimoto’s Thyroid Panel


Biotype Lab Panels

Lab Panel – Standard Biotype

How does the test and consultation process work?

Go to the Labs and Assessments page and select the test and consultation service you would like to receive. You will receive a link to complete and online questionnaire. You will then get a test form to take to Lab Corp and your urine kryptopyrrole test kit will come to you by mail. Once tests and the questionnaire are complete you will receive results. If a consultation and assessment are also ordered these will be sent via secure email and a time will be made available to talk with the physician as a follow-up to the report.

Do you use genetic tests to determine methylation status or biotypes?

Genetic tests are not used. The protocol taught by Dr Walsh utilizes histamine for determining methylation status and other biotypes are determined according the panel made available on this website.

What if I already have my lab results but just want an Assessment and supplement Plan?

Consultation and Assessments are available for persons who already have labs, as long as they were completed in the past 3-4 months. Consultation fee is a bit higher, due to the extra time involved. Sometimes tests may have to be repeated if they were drawn by a less reliable source or appear ambiguous. 

Can you bill my insurance?

Second Opinion Physician does not bill insurance at this time. However upon request a statement will be provided with CPT codes and fees spent for the labs and consultation. Sometimes insurance or private funds will apply this to your deductible or reimburse for the services.

What are the Biotypes of Depression?

The 5 Biotypes of Depression is a term developed by Dr Walsh of the Walsh Institute to describe the primary biochemical classifications of mood and behavior disorders. When a practitioner knows one's biotype, then a specific nutrient strategy can be applied to the treatment strategy. 

What are the key influences on brain function identified through the Walsh Panel?

The key underlying factors influencing one's mood and behavior are the 1) the epigenetic (methylation) influences upon neurotransmitter activity and, 2) nutrition and the ability for key biochemical processes to take place and, 3) oxidative stress, an important indicator of need for nutrient and lifestyle management.

How do I determine my "biotype"? 

Your biotype will be determined by the results of the labs. For a full set of the Walsh Biotype we recommend doing the Comprehensive Biotype Panel with Consultation. If you are just looking to determine if you have one or another Biotype imbalance, consider ordering one of the following. Overmethylation or Undermethylation biotypes are determined by a whole blood histamine test. Copper Overload requires copper, ceruloplasmin and zinc tests or the combo Copper Overload test panel. For kryptopyrroles order the Pyrrole Urine Test

What does the term "methylation" have to do with depression?

Methylation is a term that describes the status of DNA activity in the production of proteins, enzymes and immune globulins. Overmethylators tend to have an underactive DNA 'transcription' process, whereas undermethylators have an overactivity of cellular function. 

Why does the therapy have to be individualized for each person?

As an example, individuals with overmethylation and overmethylation can experience mood disorders. Overmethylators issues arise from overactive serotonin and dopamine activity, while undermethylators it is due to an under active neurotransmitter activity. Addressing this imbalance is a major consideration in nutrient therapy. This is why treatment must be individualized.

Is Second Opinion Physician affiliated with the Walsh Institute?

Second Opinion Physician is independent from the non-profit Walsh Research Institute.

Where can I purchase supplements?

You may purchase supplements from any reputable source. Dosages and ingredients are provided with Assessment reports. To simplify the process of purchasing supplements online Second Opinion Physician has set up a website offering the top professional brands. It is called Biotype Nutrients. Supplements are categorized according to one's "biotype", a classification system developed by Dr Walsh.

How do I know what test to order?

If you are interested in a complete Walsh Panel with interpretation and supplement recommendations by the SOP Doctor then you'll want to order the "Lab Panel - Comprehensive Biotype". Be sure to select option "Diagnostic Test with Consult and Detailed Report".

I've already had a Second Opinion Comprehensive Panel. What follow up test do I order?

The initial Comprehensive Biotype Panel includes tests that do not necessarily have to be repeated.  If any of the following labs were out of balance then you may wish to repeat in 3-6 months. This includes one or more of the individual biotype lab tests such as vitamin D, homocysteine, copper, ceruloplasmin and zinc. Histamine and pyrroles do not have to be repeated unless we are uncertain about the results due to test handling or concurrent use of medicines or supplements. If you would like support in Assessing these results, consider options