Connecting patients with practitioners for an alernative approach to mental health care

Second Opinion Physician is a telemedical mental health website offering lab testing, consultation, and nutritional protocols for mood and behavior disorders.

Focus on Mental Health

Second Opinion Physician is a telemedical mental health website with a testing and treatment protocol focused on the utilization of the Walsh Approach.

The development of this site was inspired by a personal experience I had helping a loved one struggling with stress and anxiety. All prior attempts to treat the condition were met with limited success, and at times, worsened as a result of taking medicines. We really wanted to get to the root of the issue, and thanks to the guidance of Dr Walsh, we saw an incredible improvement in her condition.

Having witnessed results first hand and so decisively, led me down a path to change the focus of my practice and ultimately create this site to expand the opportunity to help others with similar needs.

Second Opinion Physician Approach

The approach we take at Second Opinion Physician, in utilizing the Walsh approach, prioritizes the following:

  • Identifying abnormal neurotransmitter activity 
  • Normalizing neurotransmitter rate

Our focus is on the activity of serotonin, dopamine, norepinephrine, and NMDA neurotransmitters as they are most important for the majoriyt of all mental disorders.

Before this approach was developed and prior to the use of SSRI drugs, scientific research pointed to stabilizing metabolism and providing nutrients that raise the production of these neurotransmitters, monoaminoxidase inhibitors, aka MAO inhibitors (neurotransmitters are "mono-amines"). Today some clinicians still focus on these levels vs the activity of the neurotransmitter and supplement with nutrients such as 5HTP, tryptophan, tyrosine and other precursors.

But by the mid 1980's science began to recognize that neurotransmitter activity was more important and so they developed drugs such as SSRI's that normalized transmission rates by regulating uptake.  This approach replaced the use of precursor nutrients and drugs like MAO inhibitors.

Our goal is in adjusting the activity rates, through reuptake by using epigenetic factors and the nutrients that influence the uptake of the neurotransmitters. With epigenetics influence on activity vs genetic SNPS (COMT, or MAO SNPS etc). That's because the latest research with respect to SSRI type drugs, has show that it is possible to correct reuptake transporter enzymes (SERT, DAT and NE transporters), with nutrients and epigenetics, instead of medicines.

Epigenetics is far more useful than genetic SNPs for addressing neurotransmitter activity, at this point in time. For that reason we rely less on genetic SNPs and more on determining methylation status and the factors that have the greatest impact NT reuptake. This includes acetylases, methylases, deacetylases, demethylases, DNA enzyme inhibitors, undermethylation, overmethylation, the methyl-acetyl competition at histone tails including methyl/folate ratio, etc.

SNPs represent the structure and function of genetically expressed proteins.  Epigenetics and the focus of our efforts at Second Opinion physician, deals with the modification of gene expression, rather than the genetic code itself. That doesn't mean we don't address neurotransmitter levels.

When addressing both the activity and nutrient precursors of neurotransmitters we look carefully at the major factors influencing these functional pathways. That includes urinary pyrrole levels an important cause of vitamin B6 and zinc deficiency. These precursors of serotonin and dopamine. We also address elevated free copper which influences the conversion of dopamine to norepinephrine. Other key nutrients that play a role in both methylation and acetylation of the DNA histone plus neurotransmitter activity include vitamin D, homocysteine, methionine, SAMe, folic acid, niacin, choline, DMAE, vitamin C, magnesium, manganese, copper, ceruloplasmin, selenium NAC, ALA.

Finally there are various amines, peptides, amino acids, purines and monoamine enzymes and other nootropic factors that play an important role in mental disorders that we like to take into consideration. This includes palmitoylethanolamide (PEA) an mono amine, DAO diamine oxidase, phenylethalamine (another compound with similar acronym PEA), low dose naltrexone and of course the diet, gut microbes and digestive tract that impacts the procdution and uptake of these nutrients, amino acids and proteins.

These are contemporary developments in the care of mental disorders that are implemented when using the Walsh approach, practiced here at Second Opinion Physician, plus additional remedies that have been refined over the years through the practice of functional medicine.

Meeting Dr William Walsh PhD.

I first heard Dr William Walsh PhD give the keynote presentation at an ACAM (American College for Advancement in Medicine) conference  at a medical conference in 2012 and was taken by his extraordinary research and strategy for classifying mood disorders per his concept of the "Five Biotypes of Depression." His understanding of the five key biochemical factors that influence neurotransmitter activity and mood disorders was very exciting.

His logic resonated loudly when he spoke to a luncheon filled with chelation practitioners. His opinion that chelation therapy was not as important as daily antioxidant therapy was insightful because it recognized the physiology of tissue and that there is a unavoidable half-life that determines heavy metal release from the body. While EDTA chelation therapy may pull an excessive amount of metal from the body each whenever administered, metals will regardless take a specific amount of time to be removed, depending on the nature of the metal and not the influence of chelators. Because heavy metals have a half life of months to years, then regardless of the increased removal following chelation, there will remain a persistence of metals in the tissue and only a gradual release. The oxidative stress from metals leaching from the tissue is best addressed by a strong antioxidant protocol, given on a regular basis. His logic was compelling and hence I was curious to give his Walsh Protocol a try for managing patients, and friends mood disorders.

It didn't take long to become fully convinced that the Protocol was showing great promise, and so I began to utilize the Walsh protocol with just about every other patient in my practice.  Having worked with many patients suffering with a wide variety of mental illnesses, often taking 5 or more different psychotropic drugs simultaneously, this nutritional approach to managing brain disorders was the most exciting thing I had learned and in all my years of practicing medicine. I wouldn't be surprised if the research of Dr Walsh PhD and Carl Pfeiffer and the Walsh Protocol will soon be considered to be a major turning point in the practice of psychiatry.

Our Network

Second Opinion Physician is a website platform for networking patients with practitioners who utilize natural therapies to all varieties of health conditions.

As a telemedicine affiliate program, the site would be used to feature physicians and ancillary practitioners across all specialties. The primary objective was to create a secure and easy to use platform where doctors could collaborate with patients to address their needs.

When we set out to create a secure platform our objective was to integrate an EMR system with encrypted questionnaire and email systems that assure patient data protection. We also work with various labs to offer the "Walsh-approach" analytics and behavior and mood classifications in our Biotype Assessments. Now that that has been achieved, it is time to expand the practice to include other telehealth providers and to network patients with like-minded practitioners in their own community.

With more practitioners participating in this network, there will become a greater collective brainpower and accessibility to address the needs of patients who find it difficult to get treated in their isolated metropolitan or rural areas.

There are often many other conditions that contribute patients illness and need attention when treating mood and behavior disorders. This includes SIBO Small Intestinal Bacterial Overgrowth and Leaky Gut Syndrome, MCAD Mast Cell Activation Disorder and other Immune Disorders,  PTSD and Traumatic Brain Disorder, Abuse and Emotional Trauma, Endocrine Disorders, Environmental Sensitivities, Genetics and Biochemical Dysfunctions. By working with experts in all these areas, patients who visit this site will be given a greater opportunity to improve their well being.

Today, the website is expanding to create a telehealth jobs network for like minded practitioners who also utilize the Walsh Protocol in their practice.

By early 2019, we hope to have a dozen or so practitioners from across the country who will become a part of this telemedicine affiliate program.

telehealth jobs

Founder of Second Opinion Physician

In 1986 I completed medical school at the Texas College of Osteopathic Medicine and Internship at Flint Osteopathic Hospital. Prior to that I grew up in Dallas, Texas and studied psychology and art at the University of Texas and University of California at Berkely. Since then I ran a private practice clinic in Atlanta, the Little 5 Points Medical Clinic, for quite a few years, offering chelation therapy, IV vitamins, oxygen therapy and functional medicine. Over the course of time I also launched an aromatherapy brand and distribution company called Earth Solutions and a sustainable soil-less garden equipment company called Bioponica. Biotype Nutrients was launched a year ago to make supplements available to patients who were treated via the Second Opinion website to assist in the sourcing top brands of nutrients organized according to each persons unique "biotype." While I continue to manage those other businesses, my priority is in the practice of functional medicine and the growth of Second Opinion Physician.

William Walsh Practitioner

Walsh Institute Professional Training Events

Walsh Institute Conference


Request Free Pre-Consultation or General Inquiry

Mood and Behavior Disorders Treated

Alcohol Abuse
Anger Management
Antisocial Personality
Asperger’s Syndrome

Bipolar Disorder
Borderline Personality
Chronic Relapse
Developmental Disorders
Drug Abuse
Eating Disorders
Emotional Disturbance
Learning Disabilities
Medication Management
Narcissistic Personality

Obsessive-Compulsive (OCD)
Oppositional Defiance
Sleep or Insomnia
Substance Abuse
Suicidal Ideation
Trauma and PTSD
Weight Loss

To understand more about the Walsh Protocol for mood and behavioral disorders and learn how it may be of help toyou or a loved one, follow our blog and be sure to get a copy of Dr Walsh’s revolutionary book Nutrient Power; Heal Your Biochemistry and Heal Your Brain.  Through analysis of over 50,000 patient labs profiles, his collective research has established a clear nutritional strategy for correcting improving ones neurotransmitter status through balancing underlying brain chemistry issues.

Learn more about our protocol and fees here.



Dr Dave is a talented compassionate integrative physician. He places his patients 1st and utilizes cutting edge therapies that help patients regain optimal health. I enjoyed working along side him and I highly endorse his clinical skills. Not only do I recommend that patients see him but I myself as an integrative physician would consult with him about my own healthcare needs. Read More

 Gez Agolli NMD, PhD, DrPH
Managing Director at Progressive Medical Center –Maxmanc Inc

Dr. Epstein came to our community as a family practice physician in the late 80s. I noticed that he was an osteopath, with a respectful, holistic approach to treating the body. Our community was so grateful that he chose to be our doctor. It was the birth of my son that made me question the medical model of treating symptoms in the body rather than supporting our bodies so they in turn are able to take care of us. Read More

Anita B.
Patient of Dr Dave

Dr. Epstein, Thank You so much!!! I have finally gotten to an optimal state of cognitive health. Your tailored supplements have given me a sense of wellbeing which I never had. I always suffered from ADD and for few years, took Adderall. The Adderall kept me dependent, and at best, masked the symptoms. Following your recommendation, I no longer need Adderall. My ADD symptoms are being addressed in a proper way. Read More

Patient of Dr Dave