How To Cure Alzheimer's
Summary of video. What you need to check; what you need to do:
The Cognoscopy is a test panel that Bredesen describes to gain a clear picture on the risk of Alzheimer's. These tests don't need to be done all at once, but a full perspective will cover the vast majority of causes of brain inflammation and Alzheimer's dementia.
Video discusses primary factors to end Alzheimer's:
- Genetic test - are you a carrier of APOe4 genetic mutation? If so, you'll want to consider fasting for 14-16 hours per day to reduce amyloid plaque.
- Hormone Levels - Vitamin D, estradiol, pregenenolone, progesterone, DHEA, testosterone, TSH, T3, reverse T3. Hormones are neuroprotective.
- Vitamins - B12 - ignore the 2 standard deviation rule, levels should be above 500
- Minerals - Plasma zinc and RBC magnesium are commonly deficient. Sufficient levels of zinc and magnesium is a must!
- Exercise - Both aerobic and muscle strengthening are necessary.
- Insulin - HgA1C, fasting glucose, insulin - optimization of insulin sensitivity is the goal.
- Toxins - What toxins are you carrying? Mercury, lead arsenic, molds, endotoxins from gut bacteria, copper/zinc ratio
- Avoid Statin Drugs - some improve because it reduces inflammation but there are better ways to do this. Memory loss is a common side effect.
- Get the book; The End of Alzheimer's. Dr Bredesen's book explains this in full detail. It' covers the condition, tests and reason these tests and treatment approach is effective.
- Use this checklist as an Alzheimer's Test Panel - Cognoscopy Checklist
- Take the Cognoscopy questionnaire
The following is an excerpt from the MPI Cognition™ website:
Of the 318 million Americans currently living, 45 million will develop Alzheimer’s disease during their lifetimes if we do not do something to prevent and reverse cognitive decline. Many others will suffer from vascular dementia or Lewy body dementia or other forms of dementia. Loss of mental faculties has become the #1 concern of aging Americans.
Medicine is undergoing a radical transformation, from 20th-century medicine to 21st-century medicine: 20th-century medicine uses small data sets—like looking at sodium and potassium but not the genome or metabolome or epigenome—to attempt to diagnose very complex illnesses in very complicated organisms—human beings. 20th-century medicine makes a diagnosis of what—Alzheimer’s or cardiovascular disease or hypertension—without understanding why. 20th-century medicine uses a one-size-fits-all, monotherapeutic approach, and has been largely unsuccessful in treating chronic illnesses such as Alzheimer’s disease, other neurodegenerative conditions, cancer, and cerebrovascular disease.
Such an approach was used to bring about the first reversal of cognitive decline in patients with early Alzheimer’s disease or its precursors, MCI (mild cognitive impairment) and SCI (subjective cognitive impairment), published in 2014 (Bredesen, Aging 2014). MPI Cognition was established to provide the research, support, and information to make this approach available to all. We have identified multiple subtypes of Alzheimer’s disease using the extensive metabolic profiling of 21st-century medicine (Bredesen, Aging 2015), identified new and previously unrecognized causes of Alzheimer’s disease (Aging 2016), and developed a continuously evolving version of Dr. Bredesen’s original MEND program. We hope that this information, research, and support will be valuable to all in our shared goal of reducing the global burden of dementia.dates and evolution as research leads to iterative enhancements.
Am I experiencing symptoms of Alzheimer's?
The 7 Early Signs of Dementia and Alzheimer’s:
- General fatigue
- Constipation or digestion issues
- Apathy, depression or withdrawal
- Change in personality
- Memory loss
- Difficulty with learning or concentration
Dr. Bredesen’s laboratory focuses on identifying and understanding basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective treatments for Alzheimer’s disease and other neurodegenerative conditions. He has collaborated on the publication of more than 220 academic research papers.
He and his colleagues have identified several subtypes of Alzheimer’s disease and has developed ReCODE – reversal of cognitive decline – a protocol that offers a new approach to treatment that has reversed symptoms in patients with mild cognitive impairment and Alzheimer’s disease.
Dr. Bredesen received his undergraduate degree from the California Institute of Technology and his medical degree from Duke University. He served as Resident and Chief Resident in Neurology at the University of California, San Francisco (UCSF). He was the Founding President and CEO of the Buck Institute for Research on Aging and Adjunct Professor at UCSF.
The biggest risk factor for developing Alzheimer’s Disease? – Whether or not you have any copies of the ApoE4 gene
- Everybody has 2 copies of the ApoE gene (1 from mom, 1 from dad) – it’s either ApoE2, ApoE3, or ApoE4
- 75 million Americans have a single copy of ApoE4
- Their lifetime risk for developing Alzheimer’s Disease is about 30%
- About 7 million Americans have 2 copies of ApoE4
- If you have 2 copies, your lifetime risk of developing Alzheimer’s Disease is over 50%
- You can test your ApoE phenotype with 23andMe
In summary, the best ways to prevent Alzheimer’s Disease:
- Eat a low inflammatory diet
- Limit your exposure to mold and other mycotoxins
- Keep an eye on your copper and zinc levels
- You don’t want your copper/zinc ratio to be too high
- About a billion people on earth are deficient in zinc – you might want to supplement
- Limit your exposure to mercury
- If you eat fish, make sure it’s wild caught, not farm raised
- Eat organic to avoid toxins
- To reverse cognitive decline. Dale recommends patients:
- Follow a mild ketogenic diet
- Fast for a minimum of 12 hours each night
- Sleep is one of the ways you clear away amyloid plaques in the brain
- Using the sauna is a great way to sweat out toxins that can lead to Alzheimer’s Disease (like cadmium, mercury, and BPA)
The research of Dr Dale Bredesen, MD is consistent with the work of William Walsh, PhD. Bredesen's focus is on factors that lead to Alzheimer's Disease, Walsh is more about mood and behavior disorders throughout life. The parallels are with markers of inflammation which influence behavior throughout life and memory and congnition later in life.
In the Comprehensive Lab Panel for a typical Walsh Assessment we look at the following:
Free Copper (zinc/copper ratio, copper/ceruloplasmin ratio and total copper)
Histamine or Doctors Data Methylation Panel (when histamine is ambiguous)
Pyroluria (as a primary cause of vitamin B6 and zinc deficiency)
Dr. Bredesen recommends that all people over age 45 get a “cognoscopy.”
This is a set of blood tests risk factors associated with the three major causes of Alzheimers. Bredesen believes that we can eradicate Alzheimer's if we protect ourselves and initiate therapies as early as possible. These markers are risk factors associated with mood and behavior disorders as well as other common morbidities related to cardiovascular health, hormonal balance, gut health and immunity.
- Dr. Dale Bredesen’s ReCODE protocol evaluates 150 factors known to contribute to Alzheimer’s disease. This identifies your disease subtype or combination of subtypes, and an effective treatment protocol can be devised
While these classifications have not become widely accepted yet, Bredesen has published two papers on Alzheimer’s subtypes, based on metabolic profiling.4 These include:
- 1. Type 1, inflammatory (“hot”) Alzheimer’s: Patients present predominantly inflammatory symptoms. They have high-sensitivity C-reactive protein, interleukin 6 and tumor necrosis factor alpha, reflecting a chronic inflammatory state. When the NF-ĸB part of inflammation is activated, it also alters gene transcription. Two of the genes turned “on” are beta-secretase and gamma-secretase, the latter of which cleaves APP, thereby promoting synaptoclastic processes.
- 2. Type 1.5, glycotoxic (sugar-toxic, “sweet, a mixed subtype: This is an in-between subtype that involves both inflammation and atrophy processes, due to insulin resistance and glucose-induced inflammation.
- 3. Type 2, atrophic or “cold”Alzheimer’s: This is classified as patients presenting an atrophic response. While a completely different mechanism from inflammation, it produces the same end result — it pushes APP in the direction of creating amyloid plaques and Alzheimer’s cell signaling.
- 4. Type 3, toxic (“vile”) Alzheimer’s: These are patients with toxic exposures. Many will have chronic inflammatory response syndrome (CIRS) markers, even though most do not fit the official criteria for CIRS. “They act like CIRS patients (in their labs, not necessarily symptoms) with dementia,” Bredesen explains.
Details of Bredesen's ReCODE:
- If You’re ApoE4 Positive, Fasting Is Strongly Indicated to Avoid Alzheimer’s
- Mitochondrial Dysfunction Is at the Heart of Alzheimer’s
- The ReCODE protocol evaluates 150 different variables, including biochemistry, genetics and historical imaging, to determine which factors are most likely driving the disease.
Alzheimer’s Key Elements in Screening Tests
|Ferritin||40 to 60 ng/mL|
|GGT||<16 U/L for men and < 9 U/L for women|
|25-hydroxy vitamin D||40 to 60 ng/mL|
|High-sensitivity CRP||<0.9 mg/L|
|Fasting Insulin||< 4.5 mg/dL|
|Omega-3 index and|
Omega 6:3 ratio
|Omega-3 index > 8 %|
|TNF alpha||< 6.0|
|TSH||Less than 2.0 microunits/mL|
|Free T3||3.2-4.2 pg/mL|
|Reverse T3||<20 ng/mL|
|Free T4||1.3-1.8 ng/mL|
|Serum copper and zinc ratio||0.8-1.2|
|Serum selenium||110-150 ng/mL|
|Vitamin E (alpha tocopherol)||12-20 mcg/mL|
|Body mass index||18-25|
|ApoE4 (DNA test)||See how many alleles you have: 0, 1 or 2|
|Hemoglobin A1c||Less than 5.5|
Practitioners who evaluate patients mental health condition look to the ratio of ceruloplasmin and total copper and plasma zinc to determine the level of oxidative stress on the body. The ratio indicates the degree of free copper. Free copper is unbound to a metallothionine, namely ceruloplasmin. Free copper has the plays a role in the brain of facilitating the conversion of dopamine to norepinephrine. The consequence of this neurotransmitter imbalance is a syndrome of anxiety, insomnia and oxidative damage to the brain.
Research by Dr William Walsh PhD has led to the classification of elevated free copper as a copper overload biotype, one of his classic 5 Major Biotypes of Depression. Controlling symptoms of copper overload involves a daily antioxidant supplement regimen plus, when zinc levels are normalized, use of an amino acid blend that Walsh has formulated that increases ceruloplasmin levels. He refers to this as "MT Promoter" a sulfur rich blend of amino acids that increase ceruloplasmin production. The use of MT Promoter has been found to be helpful in managing a number of oxidative stress conditions of the brain associated with a high copper burden, including Alzheimers Disease. A useful test to determine copper ceruloplasmin is the Copper Biotype Panel.
The causes of low ceruloplasmin can also be addressed by other means. One popular approach to treating iron overload
Other researchers have found that iron, another trace element in the body, lowers ceruloplasmin when present in the unbound oxidative form, ferrous iron. Ceruloplasmin levels rise with inflammation and tends to follow copper levels. But the wider the gap rises between total copper and ceruloplasmin indicates the degree of free copper. The same concern applies to iron. Ferritin, a protein that contains iron, is another oxidative stressor that is also associated with rising levels of HS-CRP, a cardiac inflammation marker. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593134/
Low Ceruloplasmin and Hereditary Hemochromatosis
Hereditary hemochromatosis is a genetic disorder that can cause severe liver disease and other health problems. Early diagnosis and treatment is critical to prevent complications from the disorder. If you have a family health history of hemochromatosis, talk to your doctor about testing for hereditary hemochromatosis.
What is hemochromatosis?
Hemochromatosis is a disorder in which the body can build up too much iron in the skin, heart, liver, pancreas, pituitary gland, and joints. Too much iron is toxic to the body and over time the high levels of iron can damage tissues and organs and lead to
- Cirrhosis (liver damage),
- Hepatocellular carcinoma (liver cancer),
- Heart problems,
- Arthritis (joint pain), and
In the United States, about 1 in 300 non-Hispanic whites has hereditary hemochromatosis, with lower rates among other races and ethnicities. Many people with hereditary hemochromatosis don’t know they have it. Early symptoms, such as feeling tired or weak, are common and can cause hemochromatosis to be confused with a variety of other diseases. Most people with hereditary hemochromatosis never develop symptoms or complications. Men are more likely to develop complications and often at an earlier age. An estimated 9% (about 1 in 10) of men with hereditary hemochromatosis will develop severe liver disease.
How do you know if you have hereditary hemochromatosis?
A blood test can be used to screen people who may have hemochromatosis by measuring how much iron is in their blood. Affected people with or without a known family history of hemochromatosis can be diagnosed through blood tests for iron followed by genetic testing if they are symptomatic or have complications. Symptoms of hemochromatosis include
- Feeling of tiredness or weakness,
- Weight loss,
- Joint pain,
- Bronze or grey skin color,
- Abdominal pain, and
- Loss of sex drive.
Hereditary hemochromatosis is most commonly caused by certain variants in the HFE gene. If you inherit two of these variants, one from each parent, you have hereditary hemochromatosis and are at risk for developing high iron levels. If you have a family member, especially a sibling, who is known to have hereditary hemochromatosis, talk to your doctor about genetic testing.
How can you prevent complications from hereditary hemochromatosis?
If you or your family members have hereditary hemochromatosis, your doctor may suggest ways to lower the amount of iron in your body. The earlier hemochromatosis is diagnosed, the less likely you are to develop serious complications—many of which can cause permanent problems. If you are diagnosed with hemochromatosis, regularly scheduled blood removal is the most effective way to lower the amount of iron in your body. Your doctor may also recommend
- Annual blood tests to check your iron levels;
- Liver biopsy to check for cirrhosis;
- Iron chelation therapy, if you cannot have blood removed, which involves medicine taken either orally or injected to lower the amount of iron in your body;
- Dietary changes, such as avoiding multivitamins, vitamin C supplements, and iron supplements, which can increase iron throughout your body;
- No alcohol use (because alcohol increases the risk of liver damage); and
- Steps to prevent infections, including not eating uncooked fish and shellfish and getting recommended vaccinations, including those against hepatitis A and B.
Morley Robbins is not a PhD but has a large following and an interesting approach to managing elevated free radical of iron, which potentially benefits those seeking a remedy to improve ceruloplasmin to copper ratio and manage oxidative stress of the entire body.
Steps to Increase Ceruloplasmin (Cp) per Morley Robbins:The Root Cause Protocol
- STOP Vitamin-D ONLY Supplements (Supplemental “vitamin”-D KILLS Liver Retinol that is needed for Cp) More on Vitamin/Hormone-D…
- STOP Calcium Supplements! (Ca BLOCKS Magnesium & Iron absorption)
- STOP Iron Supplements! (Iron, or Fe SHUTS DOWN Copper metabolism) More on Iron Toxicity…
- STOP Ascorbic Acid (Ascorbic Acid disrupts the Copper < > Cp bond)
- STOP High Fructose Corn Syrup (HFCS) & Synthetic Sugars (HFCS Lowers Liver Copper & Raises Liver Iron)
- STOP LOW Fat Diet (Saturated Fat is needed for proper Copper absorption)
- STOP Using Industrialized, “Heart Healthy” Omega-6 Oils! (e.g. Soybean, Corn, Canola Oils)
- STOP Using products with Fluoride (toothpaste, bottled water, etc.)
- STOP Taking “Drugstore” Multivitamins & Pre-natals (They contain the first four items above, plus trace amounts of fluoride)
- STOP Using Citrate in Foods & Supplements (e.g. “Natural Calm”)
- STOP Using Colloidal Silver as an Antibiotic (It lowers Copper status in the body! Nanonized Silver is ok)
- START Magnesium (Mg) supplements (Jigsaw Mag SRT, Pure Encaps Mag Glycinate, Mag Oil, etc. See Magnesium Supplement Recommendations) to lower Adrenocorticotropic hormone (ACTH) & Cortisol. (Dose: 5 mg/lb or 10 mg/kg body weight. Be mindful of the Mg cofactors: B6, Boron, and Bicarbonate.
- START taking the Adrenal Cocktail (4oz fresh orange juice, 1/4 tsp Cream of Tartar and 1/4 tsp sea salt) at 10am and 2pm on an empty stomach to balance electrolytes.
- START Cod Liver Oil supplements (1 tsp Nordic Naturals Arctic or 1 tsp Rosita) for Retinol, animal based Vitamin A.
- START Whole Food Vitamin C supplements (Innate Response tablets or Pure Radiance Synergy powder: 400 – 800 mg/day (Key source of Copper)
- START Using Mother Nature sources for B Vitamins:
– take ½ tsp of Bee Pollen
– take 1 – 2 tsp of Rice Bran (be sure to take AWAY FROM other foods)
– eat 4 – 6 ounces of Beef Liver weekly
(research shows that several B vitamins are KEY for Cp production. Please get these as noted above:) B2 (Riboflavin) – Key for Cu/Fe regulation in the liver; B5 (Pantothenate) – Supports the production of Vitamin C; B7 (Biotin) – Key for Cu/Fe regulation in the liver.
- START Using Silica (Diatomaceous Earth) that stimulates an increase in Cp! (Start with 1 tsp in water at the start or end of the day, and work up to 3 tsp [1 Tbs] each day.)
- START Boron (1 – 3 mg/day, or add 1 Tbs borax to magnesium baths) – aids in Synthesis of Cp, and regulation of Fe.
- START Taurine (500 – 1,000 mg/day) Supports liver copper metabolism
- START Ancestral Diet (HIGH Fat & Protein/LOW Carb) Good for Copper absorption
- START Iodine (PREREQUISITE: Mg RBC & Se RBC need to be optimal) Until then, add Iodine rich foods like kelp, seaweeds, scallops, cod, eggs, cranberries, etc. to the diet.
Alzheimer’s and MT Promoter developed by Dr William Walsh Phd.
NOTES FROM 10/18/16
Notes from Dr Walsh’s presentation at the October 2016 Physician Workshop and Training Conference.
Alzheimers was named after the Doctor bearing his name. Hallmarks of this condition include
- Apoptosis – spontaneous death of cells at rate of 5000 times normal.
- Severe oxidative stress – inflammation and tissue damage.
- Neurofibrillary tangles – twisted fibers inside brain cells. Derived from microtubules that are responsible for transporting nutrients to nerve cells.
- Metal problems – initially believed to be aluminum, then brain volume, then concentration of aluminum. Theory of metal toxicity is back in favor with issues of role of copper and zinc recognized as playing a more important role.
Dr Walsh has developed an amino acid blend, called MT Promoter which is intended to improve metallothionein protein production. One such protein, ceruloplasmin is important for binding or chelating ‘free metals’. Unbound copper and other metals are free radicals that cause tissue damage. From a neurotransmitter standpoint, free copper lowers dopamine, the reward and executive thought neurotransmitter, and raises levels of norepinephrine, an excitatory neurotransmitter. To prevent this conversion and avoid other effects of oxidative stress, we like to increase these binding proteins. In addition to MT Promoter, binding proteins level improves with improved consumption and digestive uptake of protein. Metallothionein proteins are found in border cells of the digestive track and brain. They are believed to be a first line of defense against free radical damage.
There are believed to be two types of Alzheimer’s conditions:
- Genetic – runs in some families – out of 5-6 siblings, 1-3 will get this, as they get progressively older
- ApoE – genetically expressed proteins – Believed now that 50% of people 85+ have some amount
Signs and symptoms of progressive worsening condition:
- Early warning signs – often as early as 55-60 years old
- Lose interest in schedules – move away from life
- Why recent/old – as memories formed, as sensory nerves strike outer part of brain and lay down inputs, memories are processed, info transferred to hippocampus and base of brain parts, processed/organized, then back where it came from and laid down as memory
- Moderate symptoms
- Inability to form new memories
- Years 4-6
- Often require nursing home – though may not be bothered by this
- Later stage
- Complete loss of speech and response
- Some may have some understanding of who’s there but unable to respond
Risk Factors for Alzheimer’s
- Only realized in mid-50s had something to do with age
- Prior didn’t have long enough lifespan
- Many documented cases of boxers
- Family of well-known boxers in England – all developed
- Also football players – more and more cases now
- Education – big surprise
- Someone in MI developed ability to measure amyloid plaque level in alive human being – proportional to disorder in autopsies
- People who never went past HS, vs. college – factor of 5 difference – Even stronger if didn’t finish 8th grade
- Keep mind as active as possible
- If retired and learn new language or learn something new
- Sedentary FAR more likely
- Vascular Alzheimer’s Disease – not vascular dementia
- Most begins very close to blood vessels
- People with hypertension AND hypotension are more prone
- Alcohol abuse – factor 2-3
- Toxic metals – seen in high levels
- Poor nutrition
- Lots to do with glial cells nourishing all neurons
- Need nutrition to stay healthy, or neurons deteriorate and die
Diagnostic tests for Alzheimer’s:
- MMSE – common
- Best test – CANTAB – from Yale
- Like video game test – spend 45” going through the test
- Measures many cognitive functions, not just memory
- He got that to test his people pre/post
- Odor discrimination – entorhinal cortex is first to go
- Scratch and sniff, differentiate smells in multiple choice
- Correctly tell 10+ – very low likelihood of Alzheimer’s Disease development
- If 2-4, chances within 5 years much higher
- He gave to a good friend, who flunked the test – dad had died of Alzheimer’s Disease
- Had been getting affairs in order, then found out had a bad cold that day!
- Totally normal on retest, repeated since
- Direct measure
- Not yet FDA approved – research only
- Amyloid – losing favor
- They have gunky material in brain when they die
- As it grows, when it touches neuron, it dies – they thought
- 12-13 years ago – discovered drug to eliminate plaque from rat brains, rushed to human testing
- At first, so exciting. Got rid of plaques with mild-mod Alzheimer’s Disease
- Bad news – didn’t change trajectory of disease – still deteriorate and die
- Makes the tangles
- Still leading theory
- Could be this alone?
- Curcumin theory – India incidence of Alzheimer’s Disease in old people – 90yo – very small
- Curcumin very able to reduce inflammation in brain
- Oxidative stress
- Present in almost every neurodegenerative condition
- Toxic metal causation
- Persuasive Alzheimer’s Disease research on copper
- Could also be glial and nutrition related
- Small protein, linear
- Cysteine is great antioxidant
- When replaced progressively by arginine, raises risk
- Most people with Apoe4 don’t get it – 40-45%
- 40% of Alzheimer’s Disease have neither
- Can improve symptoms 6-12 months (actually 4-6 in practice)
- Does not stop progress
- Enables dying brain to function a bit better – just what’s left works better
Case for Metallothionein:
- As much as anything else in brain, protective of metals
- If don’t have above-average levels of these metals, highly unlikely to form plaques
- Fresh brains with and w/o Alzheimer’s Disease – those who died OF Alzheimer’s Disease had less than 1/3 of normal conc
- Very intriguing
MT Promoter for Alzheimers:
- He had already developed for autism
- Formulation of 22 nutrients that promote synth and fxn of MT
- They looked at over 900 studies to see which nutrients promote expression of Alzheimer’s Disease, and which promoted function of brain once expressed
- They found by taking it themselves that there ARE side effects if low in Zn
- Zn is a metal-regulating element actually on DNA – tends to promote expression of MT
- But, it gets expressed without Zn (naked molecule) which immediately grabs Zn, dropping blood level, and causing irritability
- Zn loading followed by MTP
- Do this till plasma zinc reaches 100 mcg/dL
- Aimed at overcoming brain oxidative stress and inflammation, and repair of the BBB
- Prevents bad stuff from coming in
MT Promoter for Alzheimer’s Disease:
- Unproven until RCTs confirm efficacy
- Very promising results
- Don’t give to anyone without good quality of life – don’t preserve them in state of misery, so NOT advanced
- Have to have caretaker