Category: Walsh Protocol & Biotypes
The Walsh Protocol identifies five core biochemical patterns—called the Five Biotypes of Depression—that explain why people respond differently to medications, supplements, and stress. These biotypes include undermethylation, overmethylation, copper overload, pyroluria, and toxic overload. Each pattern reflects a distinct imbalance in neurotransmitter activity, nutrient status, and gene regulation that can be measured through targeted lab testing. Posts in this section explain how to recognize each biotype through symptoms and lab markers such as histamine, SAM/SAH, copper, zinc, ceruloplasmin, pyrroles, and homocysteine, and how personalized nutrient therapy can restore balance. The goal is to replace trial-and-error psychiatry with a biochemical roadmap—helping identify which nutrients to use, which to avoid, and how to address the root causes of mood and behavior changes using evidence-based nutritional psychiatry.
Copper Overload Symptoms: Causes, Testing & Effective Treatment
Copper Overload Symptoms – Updated Science on Neurotransmitters, Ceruloplasmin & Walsh Theory Copper overload symptoms [...]
Understanding the Methylation Test: How to Identify Undermethylation and Nutrient Imbalances
Understanding the Methylation Test: How to Identify Undermethylation and Biochemical Imbalances Many people learn about [...]
Symptoms of Copper Overload – Causes, Testing and Treatment
Symptoms of High Copper Levels: Causes, Testing & Treatment Options Copper is essential for human [...]
What Is Pyroluria? Pyrrole Disorder Symptoms, Testing & Treatment Guide
What Is Pyroluria? Understanding Pyrrole Disorder, Symptoms, Testing & Treatment Many people search for what [...]
Autism Signs & Symptoms | Biotypes, Undermethylation, Copper Overload & Oxidative Stress
Autism Signs & Symptoms Explained Through Biochemistry, Methylation, and Oxidative Stress Parents searching for early [...]
Raising Ceruloplasmin to Improve Copper Overload Symptoms
How to Increase Ceruloplasmin Naturally: Understanding Copper Balance, Free Copper, and Mental Health If you’re [...]
Homocysteine and Methylation | Manage Homocysteine to Help Undermethylators
Homocysteine – Understanding Homocysteine and Methylation: A Functional Medicine Perspective Homocysteine sits at the center [...]
Vitamin D Therapy Interview | Dosage, Methylation & Serotonin Effects
Vitamin D Therapy Interview | Testing, Dosage, Methylation & Serotonin Effects Interviewer: Dr. John Campbell [...]
Fragile X Syndrome: Genetic Testing, Symptoms & Support
Fragile X Syndrome: Understanding Genetic Testing and Supportive Nutrient-Based Options Fragile X Syndrome is one [...]
Undermethylation and Autism
Undermethylation in Autism – What the Plasma Methylation Panel and SAM:SAH Ratio Reveal Methylation is [...]
Copper, Oxidative Stress & Autism
Copper, Oxidative Stress, and Autism – The Hidden Chemistry Behind Behavior Copper and zinc are [...]
Undermethylation, Autism & Mitochondria
Undermethylation, Autism and Mitochondrial Dysfunction Autism is often discussed in terms of behavior or learning, [...]
Folate, MTHFR and Depression – Misunderstood Connection
Why MTHFR genetic test and therapy with methylated folates is not advisable for treating undermethylated [...]
Folinic Acid for Autism – FRAT Testing
Leucovorin for Autism: What Parents and Clinicians Should Know Families and clinicians are exploring whether [...]
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How to Remove Toxins & Improve Methylation
How to Detoxify the Kidneys to Improve Methylation: Insights from Dr. Robin Rose The kidneys [...]