Category: Walsh Protocol & Biotypes
The Walsh Protocol identifies five core biochemical patterns—called the Five Biotypes of Depression—that explain why people respond differently to medications, supplements, and stress. These biotypes include undermethylation, overmethylation, copper overload, pyroluria, and toxic overload. Each pattern reflects a distinct imbalance in neurotransmitter activity, nutrient status, and gene regulation that can be measured through targeted lab testing. Posts in this section explain how to recognize each biotype through symptoms and lab markers such as histamine, SAM/SAH, copper, zinc, ceruloplasmin, pyrroles, and homocysteine, and how personalized nutrient therapy can restore balance. The goal is to replace trial-and-error psychiatry with a biochemical roadmap—helping identify which nutrients to use, which to avoid, and how to address the root causes of mood and behavior changes using evidence-based nutritional psychiatry.
Walsh Research Institute | Nutritional Psychiatry & Walsh Protocol
Walsh Research Institute, Orthomolecular Psychiatry, and Nutritional Psychiatry – Clarifying the Science The Walsh Research [...]
Folic acid worsens depression | Why MTHFR testing fails depression treatment
SECOND OPINION SERIES Folic Acid Worsens Depression | Why MTHFR Testing Fails This article explains [...]
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Walsh Protocol Explained: Nutrient Therapy for Depression, Folate Risks, and Key Nutrients
SECOND OPINION SERIES Walsh Protocol Explained: Why Nutrient Therapy Works When Psychiatric Labels Fail The [...]
Understanding Methylation: Symptoms, Histamine Balance, and the Best Tests for Mental Health
SECOND OPINION SERIES What Does Methylation Mean in the Body? Methylation is one of the [...]
High Basophils and Histamine: Understanding Undermethylation, Depression & Walsh Biotypes
SECOND OPINION SERIES High Basophils, Histamine, and Methylation – Second Opinion Series Understanding Increased Basophils: [...]
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High Copper Symptoms: A Second Opinion on Anxiety, Dumping Episodes & How to Test for High Copper
SECOND OPINION SERIES High Copper Symptoms and the Biochemical Cause Copper plays essential roles in [...]
Understanding the Methylation Test: How to Identify Undermethylation and Nutrient Imbalances
Understanding the Methylation Test: How to Identify Undermethylation and Biochemical Imbalances Many people learn about [...]
What Is Pyroluria? Pyrrole Disorder Symptoms, Testing & Treatment Guide
What Is Pyroluria? Understanding Pyrrole Disorder, Symptoms, Testing & Treatment Many people search for what [...]
Autism Signs & Symptoms | Biotypes, Undermethylation, Copper Overload & Oxidative Stress
Autism Signs & Symptoms Explained Through Biochemistry, Methylation, and Oxidative Stress Parents searching for early [...]
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Raising Ceruloplasmin to Improve Copper Overload Symptoms
How to Increase Ceruloplasmin Naturally: Understanding Copper Balance, Free Copper, and Mental Health If you’re [...]
Homocysteine and Methylation | Manage Homocysteine to Help Undermethylators
Homocysteine – Understanding Homocysteine and Methylation: A Functional Medicine Perspective Homocysteine sits at the center [...]
Vitamin D Therapy Interview | Dosage, Methylation & Serotonin Effects
Vitamin D Therapy Interview | Testing, Dosage, Methylation & Serotonin Effects Interviewer: Dr. John Campbell [...]
Fragile X Syndrome: Genetic Testing, Symptoms & Support
Fragile X Syndrome: Understanding Genetic Testing and Supportive Nutrient-Based Options Fragile X Syndrome is one [...]
Undermethylation and Autism
Undermethylation in Autism – What the Plasma Methylation Panel and SAM:SAH Ratio Reveal Methylation is [...]
Copper, Oxidative Stress & Autism
Copper, Oxidative Stress, and Autism – The Hidden Chemistry Behind Behavior Copper and zinc are [...]