Category: Undermethylation
Undermethylation is a pattern marked by low serotonin and dopamine activity, often seen with inner tension, persistent low mood, perfectionistic drive, and strong achievement orientation. In this section, posts explain how the SAM:SAH ratio and related labs point to low methyl availability, why folates and niacin are often limited in undermethylated profiles, and how targeted supports—SAM, methionine (when indicated), and creatine to spare methyl groups—can help. Guidance also covers zinc and vitamin D for neurotransmitter and immune support, B6 and magnesium for cofactor needs, gut integrity to improve nutrient absorption, sleep and stress hygiene, and gentle alkalinizing strategies (e.g., baking soda protocols) that can ease toxin burden. Diet ideas emphasize adequate protein, mineral-rich vegetables, and low-glycemic carbohydrates. Together, these topics outline practical ways to raise methylation capacity, support monoamine balance, and reduce the biochemical stressors that commonly track with undermethylation.
Folic acid worsens depression | Why MTHFR testing fails depression treatment
SECOND OPINION SERIES Folic Acid Worsens Depression | Why MTHFR Testing Fails This article explains [...]
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Understanding Methylation: Symptoms, Histamine Balance, and the Best Tests for Mental Health
SECOND OPINION SERIES What Does Methylation Mean in the Body? Methylation is one of the [...]
High Basophils and Histamine: Understanding Undermethylation, Depression & Walsh Biotypes
SECOND OPINION SERIES High Basophils, Histamine, and Methylation – Second Opinion Series Understanding Increased Basophils: [...]
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Understanding the Methylation Test: How to Identify Undermethylation and Nutrient Imbalances
Understanding the Methylation Test: How to Identify Undermethylation and Biochemical Imbalances Many people learn about [...]
Autism Signs & Symptoms | Biotypes, Undermethylation, Copper Overload & Oxidative Stress
Autism Signs & Symptoms Explained Through Biochemistry, Methylation, and Oxidative Stress Parents searching for early [...]
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Homocysteine and Methylation | Manage Homocysteine to Help Undermethylators
Homocysteine – Understanding Homocysteine and Methylation: A Functional Medicine Perspective Homocysteine sits at the center [...]
Vitamin D Therapy Interview | Dosage, Methylation & Serotonin Effects
Vitamin D Therapy Interview | Testing, Dosage, Methylation & Serotonin Effects Interviewer: Dr. John Campbell [...]
Fragile X Syndrome: Genetic Testing, Symptoms & Support
Fragile X Syndrome: Understanding Genetic Testing and Supportive Nutrient-Based Options Fragile X Syndrome is one [...]
Undermethylation and Autism
Undermethylation in Autism – What the Plasma Methylation Panel and SAM:SAH Ratio Reveal Methylation is [...]
Undermethylation, Autism & Mitochondria
Undermethylation, Autism and Mitochondrial Dysfunction Autism is often discussed in terms of behavior or learning, [...]
Folinic Acid for Autism – FRAT Testing
Leucovorin for Autism: What Parents and Clinicians Should Know Families and clinicians are exploring whether [...]
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The Walsh Approach: Improve Methylation with Creatine & Baking Soda
Dr William Walsh & David Epstein, D.O. Discuss A Novel Approach to Improve Methylation: Alkalinity, [...]
Diet, Environment & Body pH
Chronic Low Grade Acidosis and the Need for Alkalinization to Improve Methylation Modern lifestyles often [...]
Selecting the Best Antidepressant: How Methylation Status Can Guide Your Depression Treatment
Improve your treatment outcome by choosing the best antidepressant based on methylation status. If you’ve [...]
SAH, Methylation, and Mood: A Functional Medicine Perspective
SAH, Methylation, and Mood: A Functional Medicine Perspective” Managing Elevated SAH: Effects and Interventions Mood [...]
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