Category: Undermethylation
Undermethylation is a pattern marked by low serotonin and dopamine activity, often seen with inner tension, persistent low mood, perfectionistic drive, and strong achievement orientation. In this section, posts explain how the SAM:SAH ratio and related labs point to low methyl availability, why folates and niacin are often limited in undermethylated profiles, and how targeted supports—SAM, methionine (when indicated), and creatine to spare methyl groups—can help. Guidance also covers zinc and vitamin D for neurotransmitter and immune support, B6 and magnesium for cofactor needs, gut integrity to improve nutrient absorption, sleep and stress hygiene, and gentle alkalinizing strategies (e.g., baking soda protocols) that can ease toxin burden. Diet ideas emphasize adequate protein, mineral-rich vegetables, and low-glycemic carbohydrates. Together, these topics outline practical ways to raise methylation capacity, support monoamine balance, and reduce the biochemical stressors that commonly track with undermethylation.
Fragile X Syndrome: Genetic Testing, Symptoms & Support Options for Families
Fragile X Syndrome: Understanding Genetic Testing and Supportive Nutrient-Based Options Fragile X Syndrome is one [...]
Undermethylation and Autism
Undermethylation in Autism – What the Plasma Methylation Panel and SAM:SAH Ratio Reveal Methylation is [...]
Histamine, Methylation and Serotonin. Treating depression with folic acid is usually not a good idea!
Why MTHFR genetic test and therapy with methylated folates is not advisable for treating undermethylated [...]
Folinic Acid for Autism – FRAT Testing
Leucovorin for Autism: What Parents and Clinicians Should Know Families and clinicians are exploring whether [...]
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The Walsh Approach; Improve methylation with creatine and sodium bicarbonate
Dr William Walsh & David Epstein, D.O. Discuss A Novel Approach to Improve Methylation: Alkalinity, [...]
Creatine Improves Methylation; A Strategy for Creatine Supplemenation
Creatine Improves Methylation Creatine Supplementation: A Second Opinion Physician Hypothesis to Reduce Methylation Demand in [...]
Diet, Environment and Subtle Influences on Body pH; Alkalinity and Acidity
Chronic Low Grade Acidosis and the Need for Alkalinization to Improve Methylation Modern lifestyles often [...]
Improve Methylation with Sodium Bicarbonate: Raise pH to Lower SAH
Enzymes and Kidney Function: How Baking Soda Improves Methylation by Raising pH to lower SAH. [...]
White Blood Cells; Basophils, Histamines and Depression
Understanding the Connection Between High Basophils, Methylation, and Depression White blood cells (WBCs) play a [...]
Treat Depression Naturally: Zinc Deficiency, Copper Overload & Methylation Imbalance for Mental Health
Treat Depression Naturally: Understanding Nutrient Imbalances and the Biotypes of Depression Depression can often be [...]