Category: Walsh Protocol & Biotypes

The Walsh Protocol identifies five core biochemical patterns—called the Five Biotypes of Depression—that explain why people respond differently to medications, supplements, and stress. These biotypes include undermethylation, overmethylation, copper overload, pyroluria, and toxic overload. Each pattern reflects a distinct imbalance in neurotransmitter activity, nutrient status, and gene regulation that can be measured through targeted lab testing. Posts in this section explain how to recognize each biotype through symptoms and lab markers such as histamine, SAM/SAH, copper, zinc, ceruloplasmin, pyrroles, and homocysteine, and how personalized nutrient therapy can restore balance. The goal is to replace trial-and-error psychiatry with a biochemical roadmap—helping identify which nutrients to use, which to avoid, and how to address the root causes of mood and behavior changes using evidence-based nutritional psychiatry.