Inflammation, Glutamate, and Detox Pathways

Category: Inflammation

Inflammation is a common driver of both physical and emotional symptoms and is closely linked to the biotypes of pyroluria, copper overload, and toxic overload. Chronic inflammation promotes oxidative stress in the brain, increasing glutamate activity and NMDAR hyperexcitability, which may present as anxiety, obsessive thinking, or OCD-like patterns. Posts in this section explore how poor detoxification, high copper, low zinc, and depleted antioxidants contribute to cerebral oxidative stress and neurotransmitter imbalance. Gut inflammation from dysbiosis, processed foods, and infections also feeds this cycle, often worsening mood, cognition, and sleep. The focus is on reducing the inflammatory burden through targeted detox support, improved gut health, and nutrient repletion—especially zinc, vitamin B6, NAC, and antioxidants that regulate glutamate and oxidative stress. The goal is to calm the nervous system, restore biochemical balance, and support detox pathways that break the cycle of inflammation and neurochemical overstimulation.

Ferritin Testing: Iron Toxicity and its Links to Oxidative Stress, Gut Health, and Age Related Disease

Iron Overload: Ferritin, Toxic Overload, Liver Inflammation and Brain Health Iron, a critical mineral, is [...]

Benefits of Saunas for Detoxification

Introduction to Saunas and Dr. Rhonda Patrick Saunas have been a cornerstone of health and [...]

Migraines, Autism, Gluten & Methylation | What’s the Connection?

Migraines, Autism, and Gluten Allergies: The Underlying Role of Histamine, Undermethylation, and DAO In this [...]

Histamine Intolerance: DAO Supplements & Testing

Histamine Intolerance: DAO Supplements & Testing Histamine intolerance can significantly impact one’s quality of life, [...]

Understanding Homocysteine and Cardiovascular Risk

Decoding Homocysteine’s Role in Heart Health Cardiovascular disease remains a leading cause of death worldwide, [...]

Detoxification; Benefits of Ozone Therapy, Dry Saunas, Colonics and Toxin Avoidance

Treatment and Avoidance of Toxins to Improve Health and Wellbeing The modern world exposes us [...]

Toxic Overload, Depression and Detoxification Pathways

Toxic Overload and Depression: The Effect of Toxins on Methylation and Glutathione Depletion This article [...]

LDN Low Dose Naltrexone for High Histamine

Comparing LDN Therapy, DAO Improvement, and Methylation Support for Histamine Overload How Low Dose Naltrexone [...]

Alzheimer’s – Dale Bredesen MD; Cognoscopy Lab Test Panel

Understanding the Bredesen Protocol: A Holistic Approach to Alzheimer’s Disease Prevention and Reversal Receiving a [...]

What Are Histamines?

Inflammatory markers that also tell us about serotonin, dopamine and methylation status There are two [...]

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