Depression and Pyrrole Disorder | Urinary Pyrroles | Testing and Treatment

Depression and Pyrrole Disorder

pyrrole disorder doctor

Fifteen percent of persons with depression, tested positive for pyrrole disorder. 

This statistic is taken from the work of William Walsh, PhD and Carl Pheiffer, MD. Pyrrole Depression is one of the 5 Major Biotypes of Depression

Pyrrole Disorder is commonly associated with anxiety disorders, ODD, schizophrenia, bipolar disorder, ADHD and drug addicts.  Pyrrole disorder, aka pyroluria, aka kryptopyrroles is a red blood cell metabolic error that leads to severe deficiencies of zinc and vitamin B-6, as the pyrroles spill into the urine carrying these important nutrients.

Patients who present with pyrrole disorderhave a high level of inflammation and oxidative stress. They tend to suffer from severe mood swings and explosive anger, extreme anxieties and fears. They commonly note poor short-term memory, and have little or no dream recall.

Depression from pyrrole disorder is believed to be related to the fact that vitamins b6 and zinc play a crucial role in serotonin and dopamine synthesis. Once a person acquires this metabolic condition it has not been found to be reversible. However treatment can be quite successful with replacement of the lost nutrients plus a protocol of antioxidants, omega 6  such as animal fat, borage or primrose oil, plus GABA.  

What are the symptoms of pyrrole depression?

Mood and Emotions

  • Extreme mood swings
  • Severe inner tension
  • Severe anxiety
  • Tendency to stay up very late
  • High irritability and temper
  • History of underachievement
  • Histrionic behavior
  • Severe depression
  • Fear of airplane travel, tornadoes, etc.
  • Obsessions with negative thoughts
  • Temper Dysregulation Disorder 

Dreams and Memory

  • Little or no dream recall
  • Poor short-term memory
  • History of a reading disorder
  • Elevated kryptopyrroles
  • Mauve colored urine


  • Morning nausea
  • Tendency to delay or skip breakfast
  • Very dry skin
  • Affinity for spicy and salty foods

Body Features

  • Pale skin, inability to tan
  • White spots in nail beds
  • Sensitivity to bright lights
  • Sensitivity to loud noises
  • Poor wound healing
  • Joint pains
  • Premature graying of hair
  • Psoriasis
  • Delicate facial features
  • "Fruity" breath and/or body odor
  • Coarse eyebrow hair
  • Sretch marks (striae) on skin
  • Long arms, legs and fingers

Immunity and Inflammation

  • Autoimmune disorders
  • Severe oxidative stress
  • Poor growth
  • Delayed puberty
  • Spleen-area pain
  • Frequent infections
  • Abnormal EEG


  • Abnormal fat distribution
  • Abnormal or absent menstrual periods
  • Poor muscle development

Order Urine Pyrrole Test Now:

Biotype Individual Tests

Pyrrole Test for Depression


Pyrrole Disorder Treatment

In addition to testing, Second Opinion Physician offers Consultation and detailed Assessments that indicates the level of pyrroles in the urine and the recommended supplements based on your lab results. If you need assistance finding the best nutrients, Biotype Nutrients offers the full range of products manufactured by top rated professional brands. This website provides easy to use selection of vitamins, minerals and amino acids, etc., classified according to your nutritional 'biotype.'

Testing for pyrrole disorder:  

Second Opinion Physician provides pyrrole testing and a complete Assessment of pyrrole disorder results.  Individuals or their practitioners may order the test which is performed in accordance to the criteria established by the esteemed researcher William Walsh PhD. The pyrrole urine test tests for elevated urinary pyrroles, or kryptopyrroles in the urine. When you order the urine test kit it will be sent to your home. Instructions plus a return envelope is included to expedite the results of your sample which will be emailed to you via our secure, encrypted server. If you wish to have our Walsh-trained physician assess your condition, select one of the two consultation options when you add the test to your shopping cart. A Comprehensive Biotype Panel is also available, which includes pyrrole testing plus methylation and oxidative stress testing to determine whether or not the other four Biotypes of Depression are contributing to your condition. Follow the link and select your option for consultation. 

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