Autism & Undermethylation; Mitochondria, Oxidative Stress, Folate

Category: Autism

Autism is more than a neurological diagnosis—it is a complex biochemical pattern that can be measured, understood, and improved. Research from Dr. William Walsh and others shows that the majority of individuals with autism are undermethylated, leading to low serotonin and dopamine activity, poor detox capacity, and mitochondrial stress. Articles in this section explore how these systems interact: Undermethylation & Autism: Interpreting whole-blood histamine and the plasma methylation panel (SAM, SAH, homocysteine) to identify hidden metabolic bottlenecks. Methylation & Mitochondria: How energy production, glutathione, and creatine formation connect to focus, mood, and resilience. Copper & Oxidative Stress: Understanding copper overload autism, zinc deficiency, and antioxidant depletion that intensify behavioral reactivity. FRAT Test & Folinic Acid: When folate receptor antibodies block folate entry to the brain and why folinic acid (not methylfolate) may restore cognitive function in select cases.

Undermethylation and Autism

Undermethylation in Autism – What the Plasma Methylation Panel and SAM:SAH Ratio Reveal Methylation is [...]

Copper, Oxidative Stress, and Autism

Copper, Oxidative Stress, and Autism – The Hidden Chemistry Behind Behavior Copper and zinc are [...]

Autism & Mitochondrial Dysfunction

Methylation and Mitochondrial Dysfunction in Autism Autism is often discussed in terms of behavior or [...]

Folinic Acid for Autism – FRAT Testing

Leucovorin for Autism: What Parents and Clinicians Should Know Families and clinicians are exploring whether [...]

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Low Brain Folate in Autism, Seizures, and Neurological Disorders: The Role of Folinic Acid

Cerebral Folate Deficiency in Autism Low Brain Folate in Autism, Seizures, and Neurological Disorders: Why [...]

Migraines, Autism, Gluten & Methylation | What’s the Connection?

Migraines, Autism, and Gluten Allergies: The Underlying Role of Histamine, Undermethylation, and DAO In this [...]

Resources for Families with Adults and Children with Autism

This email was sent to me recently. I am grateful to Don at Ability Labs [...]

Dr Mercola interviews Dr Walsh; Role of nutrients for treating autism, anxiety, depression and dementia.

  It only a matter of time before Dr Walsh and his nutritional protocol for [...]

Signs and Symptoms of Autism Spectrum Disorders

An summary of characteristics of Autism Spectrum Disorders Provided by helpguide.org In both children and [...]

Assessing Cause and Treating Autistic Kids and Autism Spectrum Adults

Focus on detoxification, immune status and brain biochemistry A leaky gut syndrome is an inflammatory [...]

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