Category: OCD (Obsessive–Compulsive Disorder)

Obsessive–compulsive symptoms often track with NMDAR (NMDA receptor) hyperexcitability in the glutamate system. Excess glutamatergic drive heightens “error signals” in cortico-striatal circuits, feeding intrusive thoughts and compulsive relief behaviors. Undermethylation is frequently present, lowering serotonin/dopamine tone and antioxidant capacity, which further sensitizes NMDAR activity. Posts in this section outline a calming, multi-pathway approach: improve methylation (e.g., SAM or methionine as indicated, zinc, B6), increase glutathione and modulate glutamate with NAC, and use L-theanine and magnesium to reduce receptor overactivation. In refractory cases, NMDAR-modulating medicines such as intranasal ketamine or memantine may be considered under medical supervision. Diet focuses on lowering inflammation and limiting high-glutamate additives (MSG, hydrolyzed/“autolyzed” proteins, yeast extract), ultra-processed foods, and excess aspartame, while emphasizing Mediterranean-style meals that support gut integrity. Additional triggers that can activate/sensitize NMDAR—chronic stress and sleep loss, infections/inflammation (e.g., PANS/PANDAS), and environmental toxins—are addressed through stress hygiene, sleep regularity, and gentle detox support. The goal is to reduce glutamatergic noise, stabilize circuits, and ease OCD symptom pressure.