Symptoms of elevated histamine
More and more these days, people suffer from what are simply referred to simply as "allergies." Allergies are reactions by the body to exposure by foods and other elements that cause the body to release histamine and other biochemical elements such as tryptase, heparin, serotonin and immunoglobulins. The effect of these compounds on the tissues are known as an allergic reaction.
Treat symptoms of elevated histamine naturally
To treat symptoms of elevated histamine, the best approach is to become familiar with foods and those that contain high levels of histamine or that cause the body to produce high levels of histamine.
High serum levels of histamine lead to common inflammation conditions such as hives, skin rash, diarrhea, runny nose, high stomach acid, nausea, reflux, migraines, irregular menstrual periods, red itchy eyes, etc.
Histamine Intolerance and Mast Cell Activation Disorder
Not all histamine reactions are due to allergies. There are a number of conditions that lead to an histamine intolerance. That is true whether the histamines are derived from foods or by our excessive production of, or sensitivity to histamines.
Histamine intolerance, also referred to as histaminosis or HIT or Mast Cell Activation Disorder, may be caused by an increased release or by a lack of histamine degradation enzymes. Histamine intolerance isn't a true allergic reaction. Instead, it refers to a reaction some people experience to foods that have high levels of naturally occurring histamine. The enzymes are required for breaking down ingested or naturally produced histamines.
- DAO - diamine oxidase. This is the histamine lowering enzyme produced in the intestinal lining and by the kidneys. It circulated through the plasma and serum. Managing histamine intolerance may be addressed by supplementation with enzymes such as DAO
- HNMT - Histamine N-methyl transferase is a histamine degrading enzyme and it is found within the whole blood cells. Supplements used for symptoms associated with high red blood cell histamine including SAMe and methionine that lower histamine levels.
By treating whole blood histamine with nutrients, serotonin and dopamine levels may be corrected.
Second Opinion Physician specializes in treating mood disorders and symptoms associated with histamine imbalance within the red blood cells. Because these cells rely on the "methyl" containing enzyme (HNMT), a whole blood histamine level is useful in establishing one's "methylation status." High whole blood histamine indicates undermethylation whereas low blood histamine indicated overmethylation. Presenting his findings at the American Psychiatric Association Conference in 2015, Dr William Walsh, PhD. describes the mood related disorders of high blood histamine and low blood histamine, referring to them as undermethylation and overmethylation respectively.
In managing depression and other symptoms affected by conditions associated with histamine levels we are not specifically treating histamine. We use whole blood histamine blood levels as a measure of over or under methylation status.
Because undermethylators have low functioning levels of serotonin and dopamine, supplementing with methionine and SAMe we can increase the activity of key neurotransmitters. In addition to reducing whole blood levels of histamine, they are important regulators of enzymes involved in serotonin and dopamine reuptake. Overmethylators who, with low whole blood histamine are typically high serotonin depressives. They more frequently benefit from supplements that reduce neurotransmitter activity.