Treat Elevated Histamine, Naturally

treat elevated histamine naturally

There is a good deal of confusion regarding the role histamine plays in the body and what are factors that cause the release of histamine, increase the receptor sensitivity to histamine and the impact of histamine disorder, Mast Cell Activation Disorder.

Whole Blood Histamine as a means of measuring methylation status:

When treating mood disorders utilizing the Walsh Protocol, doctors will order a lab test that measures whole blood histamine. Histamine in blood cells is regulated primarily by an enzyme called histamine N-methyl transferase, HMT. The levels of whole blood histamine are a reflection of one's methylation status. This is because of the methyl compound that limits the ability for the HMT enzyme to break down histamine. Persons who are "undermethylated" lack, this methyl enzyme and so typically have elevated whole blood histamine levels. When treated with methyl supplying amino acids such as methionine and SAMe, the mood related disorders are often improved. Because HMT is also present in the plasma, histamine levels may be controlled to some extent with methionine and SAMe. But when suffering symptoms of elevated plasma histamine (rash, seasonal allergies, inflammation, itching, hives, conjunctivitis, congestion, etc), the enzyme diamine oxidase, DAO, is more responsible for histamine breakdown and control of these allergy symptoms.

This post below does not discuss the role of whole blood histamine and methylation for the purpose of determining cause managing methylation related mood disorders. To understand the use of whole blood histamine as a test for determine one's methylation status and serotonin and dopamine levels, please see this article.  For the record, Walsh providers prefer Whole Blood Histamine values for predicting methylation status vs genetic testing such as MTHFR and COMT genetic mutations. Walsh trained practitioners are taught that whole blood histamine is a better measure of methylation status and so is used to determine whether the causes of mood disorders such as depression are due to increased or decreased levels of serotonin and dopamine activity.

While there are many persons with elevated histamine who suffer from mood disorders, Mast Cell Activation Disorder itself if a diagnosis made from symptoms and blood tests associated with the accumulation or over expression of Mast Cells or the over response by histamine receptors.  This blog post is intended to clarify the role of mast cells and histamine as an immune reaction to antigens, foods and microbes and the symptoms plus labs used in establishing diagnosis.

Consultation with Second Opinion Physician

Complete evaluation of Walsh Panel by our Walsh-trained physician including Biotype Report, detailed supplements plan and discussion regarding test results.

Mast Cell Activation Disorder is a diagnosis based on lab tests and symptoms that indicate there is a significant immune reactivity taking place in response to various allergens, foods, microbes and other triggers.

Histamine is released from mast cells that are present in bone marrow, in circulating blood cells such as basophils and eosinophils. They accumulate along the lining of the intestines, the respiratory and sinus tract and in the vascular system. It is here where they respond to irritating or threatening triggers and lead to a cascade of immune reactive conditions that either contain the insulting element or cause harm to the body, or both.

Until recently, the only condition that was attributed to abnormal levels of mast cells and histamine was referred to as mastocytosis. This is a rare condition that required a bone bioposy to determine the degree of mast cell accumulation. Today, MCAD or Mast Cell Activation Disorder is used to describe the condition of overreaction by the mast cells and excessive release of and reactivity to compounds including histamine, tryptase, heparin and even serotonin.

Foods and Supplements That Lower Histamine

20 thoughts on “Treat Elevated Histamine, Naturally

  1. Nara says:

    Hi, o have interest of knowing more about the probiotics thay increase and the others crpas that decrease histamine. Do you have the references? Thank you só much!

    • Epstein says:
    • This is a tough questions. One pub med published study tested varieties of probiotics says can be referenced here: . Their research indicates probiotic lactobacilli strains Lactobacillus rhamnosus (L. rhamnosus) GG and L. rhamnosus Lc705 were beneficial however, bifidobacterium did not downregulate histamine activity. There are many genetic variations of many many gut flora. Hopefully future research will be able to map out the best probiotics for stabilizing mast cell activation.
  2. Missy Maiorano says:

    I have been suffering from high histamine issues…primarily hives and insomnia…ever since taking a round of Cipro. I’m waiting for my Dutch hormone testing but I already know my estrogen is extremely high and I have almost no progesterone. I’m taking Taurine, GABA, vitamin C, B-6, and zinc. I have a hunch I have low cortisol…I have always lived an extremely fast paced, super-stressed lifestyle. While I wait the 2-3 weeks for my Dutch results, will it hurt to take the taurine and GABA to calm my anxiety? I don’t want to lower my cortisol if it’s already too low…I can’t afford for my Histamine levels to get any worse.

    • Epstein says:

      Thanks for your question, however, it would not be appropriate for me to make medical recommendations via public chat without taking proper history and necessary labs.

  3. Elizabeth Keech says:

    Excellent and helpful article…Can you recommend a physician in Naples,FL who could help treat my adult daughter ? We were recently exposed to significant mold ( that she is allergic to) in our house. We are out of the house until this can be remediated next Wed. Any recommendations would be greatly aporeciated.

  4. Lee says:

    This is a great article but some of the things mentioned are things found to be high in glyphosate and glufonisate which has been found to raise histamines. They use those herbicides to dry beans and grains. Also people may want to avoid GM products because it has been found the body reacts to the BT Toxin in them the same way they would if you had food poisoning.

    • Epstein says:

      Yes, you are correct when it comes to whole foods. It is important to source organic products whenever possible to avoid glyphosates. Supplements however are not commonly available as organic. Fortunately dosages are much smaller than the source agriculture product and extracts do not likely contain glyphosates.

  5. Karlicia D. Berry says:

    This is excellent! Right on the money when it comes to explanation and advice to help. Thank you so much for publishing this.

  6. Jennifer F Jackson says:

    I find that so many who suffer with histamine problems are also sensitive to salicylates, and it is important to learn about oxalates. The best place to learn about oxalates is “Trying Low Oxalates TLO” facebook group and other groups Susan Owens is the expert. Oxalates cause kidney stones, gout, leaky gut, eye problems, joint pain, lower minerals and sulfur, if this isn’t addressed the other problems persist. Also iodine helps control histamines– and important to note meat must be very fresh (for histamines) so buy fresh and freeze right away. (No leftovers) Iodine info–– also, environmental stress is a trigger to histamine release– heat, cold, mold, … many also fine OMAD (one meal a day helps) and Intermittent fasting– at least 18 hours a day of clean fasting (Plain water only) gives the body a chance to heal — Dr. Jason Fung –“Intermittent fasting … That is the process of autophagy, where sub-cellular organelles are destroyed and new ones are …”

    • Epstein says:

      Thank you Jennifer, these are all excellent points. In regards to metals it is also important to consider copper, as it is a component of DAO. However, too much copper can also cause anxiety and ADHD, particularly if diet is inadequate or the body is low in metallothionines such as ceruloplasmin which bind free copper. Important to test copper levels prior to taking copper supplements. And a good idea to test RBC magnesium prior to taking iodine.

  7. Christine Menaged says:

    Thank you for the article. Well done.
    I have a very complex situation. I suffer from gastritis. Had my gallbladder removed do to a pancreatic attack. Everything normalized , but I continue suffering from leaky gut, gastritis, gerd post nasal drip, possible ulcers lots of burning in the gut.
    Recently developed a nagging pain that I believe may be an ulcer. I began taking Carnosine Zinc and I feel it helps my stomach, but I notice when I take carnosine the histidine makes my histamine worse. I also am gluten intolerance and recently also developed a geographical tounge which we think was a fungus infection. I was given several doses is Nystatin and Diflucan which only made it worse. I did take antibiotics a while back. I believe the Zinc carnosine can help me, but I need to balance my micro flora and control my histamine level. When I take Zinc Carnosine I get severe pain in my joints and an ache feeling as if I took gluten. My sinus are also very dry and I am always dehydrated regardless if I drink water. My E&T doctor says I have allergies but I have not suffer ed from any rashes or asthma just very dry sinus and post nasal drip. I also suffer from gerd if the acid gets out of control. Based on your article it appears I was taking the wrong probiotics.
    I would dearly appreciate any suggestion or recommendation you may have.
    Thank you,

    • Epstein says:

      Christine, thanks for your comment. It would be difficult to assess your situation from this information alone, and it would not be appropriate for me to do so in this comment section. Suggest that you have a Comprehensive Digestive Stool Analysis x 3 (I use Doctors Data) completed and start with identifying status of your digestive tract flora, parasites, yeast and food digestion. Nasal drip will disrupt the protective gastric mucosa and lead to leaky gut and a worsening of the sinus drainage. You might ask your doctor about chromalyn sodium, aka Nasalchrome. A low carb, low fruit, paleolithic diet along with a broad spectrum probiotic and other digestive support supplements should also give you some relief.

  8. Pingback: Histamine Intolerance

  9. Amanda Drake says:


    I was looking at the information on your website as I am researching to help with issues my 8yo son is suffering from…..chronic infections, chronic fatigue, rashes, chronic abdominal pain and vomiting. After much begging, we did additional blood work.

    Histamine Level= 4913 nmol/L
    Zinc= 77 ug/dl
    Copper= 115 ug/dl
    Cortisol (9am)= 5.4 ug/dl
    Ferritin= 21 ng/ml

    Any recommendations?


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