Ceruloplasmin Deficiency, Oxidative Stress and Iron | Second Opinion Physician

Ceruloplasmin Deficiency, Oxidative Stress and Iron

ceruloplasmin test

Practitioners who evaluate patients mental health condition look to the ratio of ceruloplasmin and total copper and plasma zinc to determine the level of oxidative stress on the body. The ratio indicates the degree of free copper. Free copper is unbound to a metallothionine, namely ceruloplasmin. Free copper has the plays a role in the brain of facilitating the conversion of dopamine to norepinephrine. The consequence of this neurotransmitter imbalance is a syndrome of anxiety, insomnia and oxidative damage to the brain.

Research by Dr William Walsh PhD has led to the classification of elevated free copper as a copper overload biotype, one of his classic 5 Major Biotypes of Depression. Controlling symptoms of copper overload involves a daily antioxidant supplement regimen plus, when zinc levels are normalized, use of an amino acid blend that Walsh has formulated that increases ceruloplasmin levels. He refers to this as "MT Promoter" a sulfur rich blend of amino acids that increase ceruloplasmin production.  The use of MT Promoter has been found to be helpful in managing a number of oxidative stress conditions of the brain associated with a high copper burden, including Alzheimers Disease. A useful test to determine copper ceruloplasmin is the Copper Biotype Panel.

The causes of low ceruloplasmin can also be addressed by other means. One popular approach to treating iron overload

Other researchers have found that iron, another trace element in the body, lowers ceruloplasmin when present in the unbound oxidative form, ferrous iron. Ceruloplasmin levels rise with inflammation and tends to follow copper levels. But the wider the gap rises between total copper and ceruloplasmin indicates the degree of free copper. The same concern applies to iron. Ferritin, a protein that contains iron, is another oxidative stressor that is also associated with rising levels of HS-CRP, a cardiac inflammation marker. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593134/ 

Low Ceruloplasmin and Hereditary Hemochromatosis


Hereditary hemochromatosis is a genetic disorder that can cause severe liver disease and other health problems. Early diagnosis and treatment is critical to prevent complications from the disorder. If you have a family health history of hemochromatosis, talk to your doctor about testing for hereditary hemochromatosis.

What is hemochromatosis?

Hemochromatosis is a disorder in which the body can build up too much iron in the skin, heart, liver, pancreas, pituitary gland, and joints. Too much iron is toxic to the body and over time the high levels of iron can damage tissues and organs and lead to

In the United States, about 1 in 300 non-Hispanic whites has hereditary hemochromatosis, with lower rates among other races and ethnicities. Many people with hereditary hemochromatosis don’t know they have it. Early symptoms, such as feeling tired or weak, are common and can cause hemochromatosis to be confused with a variety of other diseases. Most people with hereditary hemochromatosis never develop symptoms or complications. Men are more likely to develop complications and often at an earlier age. An estimated 9% (about 1 in 10) of men with hereditary hemochromatosis will develop severe liver disease.

How do you know if you have hereditary hemochromatosis?

A blood test can be used to screen people who may have hemochromatosis by measuring how much iron is in their blood. Affected people with or without a known family history of hemochromatosis can be diagnosed through blood tests for iron followed by genetic testing if they are symptomatic or have complications. Symptoms of hemochromatosis include

  • Feeling of tiredness or weakness,
  • Weight loss,
  • Joint pain,
  • Bronze or grey skin color,
  • Abdominal pain, and
  • Loss of sex drive.

Hereditary hemochromatosis is most commonly caused by certain variants in the HFE gene. If you inherit two of these variants, one from each parent, you have hereditary hemochromatosis and are at risk for developing high iron levels. If you have a family member, especially a sibling, who is known to have hereditary hemochromatosis, talk to your doctor about genetic testing.

How can you prevent complications from hereditary hemochromatosis?

If you or your family members have hereditary hemochromatosis, your doctor may suggest ways to lower the amount of iron in your body. The earlier hemochromatosis is diagnosed, the less likely you are to develop serious complications—many of which can cause permanent problems. If you are diagnosed with hemochromatosis, regularly scheduled blood removal is the most effective way to lower the amount of iron in your body. Your doctor may also recommend

  • Annual blood tests to check your iron levels;
  • Liver biopsy to check for cirrhosis;
  • Iron chelation therapy, if you cannot have blood removed, which involves medicine taken either orally or injected to lower the amount of iron in your body;
  • Dietary changes, such as avoiding multivitamins, vitamin C supplements, and iron supplements, which can increase iron throughout your body;
  • No alcohol use (because alcohol increases the risk of liver damage); and
  • Steps to prevent infections, including not eating uncooked fish and shellfish and getting recommended vaccinations, including those against hepatitis A and B.


Morley Robbins is not a PhD but has a large following and an interesting approach to managing elevated free radical of iron, which potentially benefits those seeking a remedy to improve ceruloplasmin to copper ratio and manage oxidative stress of the entire body.

While these steps are controversial and represent more of a collection of relevant research findings, they deserve consideration, as elevated iron is a gut toxin that feeds pathogens. Keep in mind that Vitamin D levels are important to maintain, but many find it difficult to raise levels so adding Vitamin A from cod liver oil may be helpful. Likewise, supplementing Vitamin D simultaneously with K2 has shown to improve vitamin D uptake.

Steps to Increase Ceruloplasmin (Cp) per Morley Robbins:The Root Cause Protocol


  1. STOP Vitamin-D ONLY Supplements (Supplemental “vitamin”-D KILLS Liver Retinol that is needed for Cp)  More on Vitamin/Hormone-D…
  2. STOP Calcium Supplements! (Ca BLOCKS Magnesium & Iron absorption)
  3. STOP Iron Supplements! (Iron, or Fe SHUTS DOWN Copper metabolism) More on Iron Toxicity…
  4. STOP Ascorbic Acid (Ascorbic Acid disrupts the Copper < > Cp bond)
  5. STOP High Fructose Corn Syrup (HFCS) & Synthetic Sugars (HFCS Lowers Liver Copper & Raises Liver Iron)
  6. STOP LOW Fat Diet (Saturated Fat is needed for proper Copper absorption)
  7. STOP Using Industrialized, “Heart Healthy” Omega-6 Oils! (e.g. Soybean, Corn, Canola Oils)
  8. STOP Using products with Fluoride (toothpaste, bottled water, etc.)
  9. STOP Taking “Drugstore” Multivitamins & Pre-natals (They contain the first four items above, plus trace amounts of fluoride)
  10. STOP Using Citrate in Foods & Supplements (e.g. “Natural Calm”)
  11. STOP Using Colloidal Silver as an Antibiotic (It lowers Copper status in the body! Nanonized Silver is ok)


  1. START Magnesium (Mg) supplements (Jigsaw Mag SRT, Pure Encaps Mag Glycinate, Mag Oil, etc. See Magnesium Supplement Recommendations) to lower Adrenocorticotropic hormone (ACTH) & Cortisol. (Dose: 5 mg/lb or 10 mg/kg body weight.  Be mindful of the Mg cofactors: B6, Boron, and Bicarbonate.
  2. START taking the Adrenal Cocktail (4oz fresh orange juice, 1/4 tsp Cream of Tartar and 1/4 tsp sea salt) at 10am and 2pm on an empty stomach to balance electrolytes.
  3. START Cod Liver Oil supplements (1 tsp Nordic Naturals Arctic or 1 tsp Rosita) for Retinol, animal based Vitamin A.
  4. START Whole Food Vitamin C supplements (Innate Response tablets or Pure Radiance Synergy powder: 400 – 800 mg/day (Key source of Copper)
  5. START Using Mother Nature sources for B Vitamins:
    – take ½ tsp of Bee Pollen
    – take 1 – 2 tsp of Rice Bran (be sure to take AWAY FROM other foods)
    – eat 4 – 6 ounces of Beef Liver weekly
    (research shows that several B vitamins are KEY for Cp production. Please get these as noted above:) B2 (Riboflavin) – Key for Cu/Fe regulation in the liver; B5 (Pantothenate) – Supports the production of Vitamin C; B7 (Biotin) – Key for Cu/Fe regulation in the liver.
  6. START Using Silica (Diatomaceous Earth) that stimulates an increase in Cp! (Start with 1 tsp in water at the start or end of the day, and work up to 3 tsp [1 Tbs] each day.)
  7. START Boron (1 – 3 mg/day, or add 1 Tbs borax to magnesium baths) – aids in Synthesis of Cp, and regulation of Fe.
  8. START Taurine (500 – 1,000 mg/day) Supports liver copper metabolism
  9. START Ancestral Diet (HIGH Fat & Protein/LOW Carb) Good for Copper absorption
  10. START Iodine (PREREQUISITE: Mg RBC & Se RBC need to be optimal) Until then, add Iodine rich foods like kelp, seaweeds, scallops, cod, eggs, cranberries, etc. to the diet.

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