Category: Depression
Depressive symptoms—low mood, loss of interest, slowed thinking, sleep and appetite shifts—can arise across all Walsh biotypes. Chronic, recurrent depression is more often associated with undermethylation, while other cases reflect secondary low serotonin/dopamine tone or pyroluria/inflammation with significant vitamin B6 and zinc deficiency. Less commonly, overmethylation (with comparatively higher serotonin activity) also presents with depression, but medication/nutrient responses may differ. We clarify the pattern with labs: whole-blood histamine (biotype screen), homocysteine (methylation stress), SAM/SAH when indicated, urinary pyrroles (HPL) for pyroluria, Zn/Cu with ceruloplasmin, 25-OH vitamin D, and basic inflammation/metabolic markers (e.g., CRP, ApoB/TG-HDL if energy/weight issues coexist). Care plans are individualized—protein-first meals, omega-3s, sulfur-rich vegetables to support glutathione as tolerated, low-fructose whole foods, light/sleep regularity, and biotype-matched nutrient strategies (e.g., zinc/B6 when deficient; cautious folate/methyl donors only when appropriate). This approach helps distinguish whether depression is driven primarily by undermethylation, neurotransmitter scarcity, or pyroluria/inflammation—and guides targeted, test-anchored support.
Folic acid worsens depression | Why MTHFR testing fails depression treatment
SECOND OPINION SERIES Folic Acid Worsens Depression | Why MTHFR Testing Fails This article explains [...]
36 Comments
Understanding Methylation: Symptoms, Histamine Balance, and the Best Tests for Mental Health
SECOND OPINION SERIES What Does Methylation Mean in the Body? Methylation is one of the [...]
High Basophils and Histamine: Understanding Undermethylation, Depression & Walsh Biotypes
SECOND OPINION SERIES High Basophils, Histamine, and Methylation – Second Opinion Series Understanding Increased Basophils: [...]
3 Comments
Low Glycemic Mediterranean (Methylation) Diet
Low-Glycemic Mediterranean Diet A low-glycemic Mediterranean diet supports methylation, mood, and metabolic stability by combining [...]
The Walsh Approach: Improve Methylation with Creatine & Baking Soda
Dr William Walsh & David Epstein, D.O. Discuss A Novel Approach to Improve Methylation: Alkalinity, [...]
Selecting the Best Antidepressant: How Methylation Status Can Guide Your Depression Treatment
Improve your treatment outcome by choosing the best antidepressant based on methylation status. If you’ve [...]
Concierge Telemedicine; Continued Support for Depression
Concierge Telemedicine with David Epstein, D.O. Epigenetics and Your Biochemisty: A New Way to Address [...]
SAH, Methylation, and Mood: A Functional Medicine Perspective
SAH, Methylation, and Mood: A Functional Medicine Perspective” Managing Elevated SAH: Effects and Interventions Mood [...]
Addressing Elevated SAH-S-Adenosylhomocysteine, in Undermethylation
Improving Mental Health; When Undermethylation is Exacerbated by Elevated Levels of SAH SAM/SAH Ratio in [...]
Mastering Histamine Intolerance: Low Histamine Diet & DAO Enhancing Foods
Managing Histamine Intolerance: A Comprehensive Guide on Low Histamine and DAO Enhancing Foods Are you [...]
Copper Overload and Post Partum Depression
Copper Toxicity and Postpartum Depression (PPD) Postpartum depression (PPD) is a common mental health disorder [...]
Depression and the Methylation Pathway
Methylation and Depression What is Methylation? Methylation is not one specific reaction that occurs in [...]
Barriers to Success with the Walsh Approach
Before spending money on Walsh Panel testing, or a medical Consultation it is advisable to [...]
Dave Asprey Interviews Dr William Walsh PhD. | Nutrition and Neurotransmitter Function
Dr Walsh Interview with Dave Asprey. Discussing Nutrition and Neurotransmitter Function. Summary with time stamps: [...]
Bulletproof Interview with Bill Walsh PhD – Transcript
Follow Along with the Radio Interview Announcer: Bulletproof Radio, a state of high performance. Dave: [...]
- 1
- 2