Category: Undermethylation
Undermethylation is a pattern marked by low serotonin and dopamine activity, often seen with inner tension, persistent low mood, perfectionistic drive, and strong achievement orientation. In this section, posts explain how the SAM:SAH ratio and related labs point to low methyl availability, why folates and niacin are often limited in undermethylated profiles, and how targeted supports—SAM, methionine (when indicated), and creatine to spare methyl groups—can help. Guidance also covers zinc and vitamin D for neurotransmitter and immune support, B6 and magnesium for cofactor needs, gut integrity to improve nutrient absorption, sleep and stress hygiene, and gentle alkalinizing strategies (e.g., baking soda protocols) that can ease toxin burden. Diet ideas emphasize adequate protein, mineral-rich vegetables, and low-glycemic carbohydrates. Together, these topics outline practical ways to raise methylation capacity, support monoamine balance, and reduce the biochemical stressors that commonly track with undermethylation.
Depression and the Methylation Pathway
Methylation and Depression What is Methylation? Methylation is not one specific reaction that occurs in [...]
How Folic Acid Worsen Depression in Undermethylators
Why Taking Folic Acid for Depression Worsens Symptoms, Even with MTHFR Genetic Mutations Why Genetic [...]
Foods and Supplements that Lower Plasma Histamine Levels
Foods and Antigens that Typically Raise Intestinal and Plasma Histamine Histamine rich foods: Foods that [...]
What Are Histamines?
Inflammatory markers that also tell us about serotonin, dopamine and methylation status There are two [...]
Mast Cell Activation Disorder – MCAD; Signs and Symptoms
Because of the widespread anomalies that exist in so many tissues, relating to mast cell, [...]
Mast Cell Activation Disorder – Lab Testing and Diagnosis
Diagnosis of Mast Cell Activation Disorder is made by Lab Testing and Review of Symptoms [...]
Dr Mercola interviews Dr Walsh on role of epigenetics, methylation and folates in mental health.
The Importance of Methylation and Folates in Mental Health In his interview with Dr Mercola, [...]
Signs and Symptoms of Autism Spectrum Disorders
An summary of characteristics of Autism Spectrum Disorders Provided by helpguide.org In both children and [...]
Assessing Cause and Treating Autistic Kids and Autism Spectrum Adults
Focus on detoxification, immune status and brain biochemistry A leaky gut syndrome is an inflammatory [...]
ADHD Nutrient Imbalance
#adhd in children exists in about 8-9% of the general population. However as many as 35% [...]