Category: Undermethylation

Undermethylation is a pattern marked by low serotonin and dopamine activity, often seen with inner tension, persistent low mood, perfectionistic drive, and strong achievement orientation. In this section, posts explain how the SAM:SAH ratio and related labs point to low methyl availability, why folates and niacin are often limited in undermethylated profiles, and how targeted supports—SAM, methionine (when indicated), and creatine to spare methyl groups—can help. Guidance also covers zinc and vitamin D for neurotransmitter and immune support, B6 and magnesium for cofactor needs, gut integrity to improve nutrient absorption, sleep and stress hygiene, and gentle alkalinizing strategies (e.g., baking soda protocols) that can ease toxin burden. Diet ideas emphasize adequate protein, mineral-rich vegetables, and low-glycemic carbohydrates. Together, these topics outline practical ways to raise methylation capacity, support monoamine balance, and reduce the biochemical stressors that commonly track with undermethylation.