Methylation | Second Opinion Physician

According to research scientist, Dr. William Walsh PhD, “About 30 years ago, the great Carl Pfeiffer, MD, PhD, believed that histamine’s role as a brain neurotransmitter was a central factor in schizophrenia and other mental disorders. Since Pfeiffer’s death in 1988, we’ve learned this is not correct and that methylation imbalances (a) cause abnormal histamine levels and (b) have a major epigenetic effect on mental health. Methylation is the primary process for metabolizing (destroying) histamine and there is a convenient inverse relationship between histamine levels and methylation status. Our treatments are not aimed at normalizing histamine, but in dealing with the brain disorders associated with overmethylation or undermethylation.”