Category: Creatine & Methylation

Creatine plays a vital role in energy metabolism and methylation balance. Nearly half of the body’s methylation demand is devoted to producing creatine from guanidinoacetate, making it one of the largest consumers of methyl groups. When creatine is supplemented through diet or nutrition, it reduces the body’s need to use SAM (S-adenosylmethionine) for its synthesis—freeing those methyl groups for other essential functions such as neurotransmitter production, DNA methylation, and detoxification. Posts in this section explain how creatine supports undermethylated individuals by conserving SAM and improving cellular energy, mood stability, and muscle performance. It also enhances brain function by buffering ATP production in neurons and supporting mitochondrial efficiency. Optimal benefits are achieved alongside methylation cofactors such as methionine, zinc, B6, and magnesium, with attention to hydration and alkalinity to support kidney clearance of byproducts. In the context of the Walsh Protocol, creatine serves as both a methylation-sparing and energy-supporting nutrient, improving overall metabolic and neurological resilience.