Category: Depression

Depressive symptoms—low mood, loss of interest, slowed thinking, sleep and appetite shifts—can arise across all Walsh biotypes. Chronic, recurrent depression is more often associated with undermethylation, while other cases reflect secondary low serotonin/dopamine tone or pyroluria/inflammation with significant vitamin B6 and zinc deficiency. Less commonly, overmethylation (with comparatively higher serotonin activity) also presents with depression, but medication/nutrient responses may differ. We clarify the pattern with labs: whole-blood histamine (biotype screen), homocysteine (methylation stress), SAM/SAH when indicated, urinary pyrroles (HPL) for pyroluria, Zn/Cu with ceruloplasmin, 25-OH vitamin D, and basic inflammation/metabolic markers (e.g., CRP, ApoB/TG-HDL if energy/weight issues coexist). Care plans are individualized—protein-first meals, omega-3s, sulfur-rich vegetables to support glutathione as tolerated, low-fructose whole foods, light/sleep regularity, and biotype-matched nutrient strategies (e.g., zinc/B6 when deficient; cautious folate/methyl donors only when appropriate). This approach helps distinguish whether depression is driven primarily by undermethylation, neurotransmitter scarcity, or pyroluria/inflammation—and guides targeted, test-anchored support.