FOLATE RECEPTOR ANTIBODY TEST (FRAT TEST) WITH CONSULTATION
FOLATE RECEPTOR ANTIBODY TEST (FRAT®) WITH CONSULTATION
WHAT IS FRAT (Folate Receptor Autoantibodies Test) is a specialized blood test developed by Dr. Edward Quadros at SUNY Downstate Medical Center. It is the only assay that detects both blocking and binding autoantibodies to the folate receptor alpha (FRα). These antibodies can interfere with the transport of folate (vitamin B9) into the brain and central nervous system, leading to serious neurological and psychiatric effects.
FRAT® has been validated in clinical research and is published in top-tier journals including the New England Journal of Medicine. It has been used in numerous clinical trials and is considered the gold standard for identifying cerebral folate deficiency due to autoimmunity.
WHO SHOULD CONSIDER THIS TEST? You may be a candidate for FRAT® testing if you or your child experience any of the following conditions:
- Autism Spectrum Disorder (ASD), particularly with language delay
- Cerebral Folate Deficiency Syndrome (CFDS)
- Treatment-resistant Depression
- Schizophrenia or psychotic spectrum disorders
- Developmental Delay
- Neurological regression without clear cause
- Chronic fatigue or cognitive decline
Testing is especially important in children, as early identification of folate receptor autoantibodies can improve the outcome of treatment and prevent further developmental or neurological decline.
WHY THIS TEST MATTERS The presence of folate receptor autoantibodies can significantly impair the ability of folate to reach the brain via the choroid plexus and cerebrospinal fluid. This can result in symptoms related to mood, cognition, speech, and behavior. When identified, treatment with high-dose folinic acid (leucovorin calcium) may bypass this blockage and restore brain folate levels.
Clinical Evidence: One landmark study by Frye et al. (Molecular Psychiatry, 2016) found that children with autism and language impairment who were positive for folate receptor autoantibodies showed significantly improved verbal communication after 12 weeks of high-dose folinic acid therapy. Those who were FRAA-positive had even greater benefit, with a large effect size (Cohen’s d = 0.91).
WHAT’S INCLUDED When you order the FRAT® test through our clinic, you receive:
- A physician-ordered FRAT® blood test kit (shipped to your home or local draw site)
- Symptom and history questionnaire
- Personalized consultation with Dr. Dave, trained in the Walsh Protocol and offering a functional approach to mood and behavior disorders.
- Interpretation of results with a comprehensive report
- Treatment recommendations when appropriate, including folinic acid therapy and nutrient support
ORDERING & NEXT STEPS Click below to request your FRAT® test and schedule your consultation.
Note: This test is not available without physician authorization. Your report and recommendations will be reviewed directly by a licensed physician.