Category: Overmethylation

Overmethylation is a biochemical pattern that leads to elevated activity of serotonin and dopamine. Per the Walsh Approach, this occurs when excessive methyl group activity influences histone DNA methylation, which in turn alters the expression of genes regulating neurotransmitter reuptake proteins. As a result, serotonin and dopamine remain more active in the synapse, contributing to a unique form of depression marked by anxiety, sleep disturbance, sensory sensitivity, and emotional volatility. These patients typically respond poorly to SSRIs and SNRIs, which further elevate serotonin and dopamine activity. Overmethylation is also associated with epigenetic changes affecting stress reactivity and immune balance. Lab findings often show low whole blood histamine (a reliable screening marker for overmethylation), low folate, high homocysteine, and occasionally macrocytosis on RBC indices. Treatment aims to reduce methylation activity through folic acid and niacin, along with balanced nutrient support to restore neurotransmitter regulation and improve emotional stability without overstimulation.