This test panel is the most common set of labs when following progress of supplementation for the Walsh Protocol. We do not retest histamine and pyrroles as a rule as they don’t fluctuate with supplementation even though methylation and pyrrole therapy may improve condition. The test listed below are those that are most likely to be improved with supplements; retesting helps determine need for increasing or lowering dosage.
The test includes:
- Copper, Serum – Elevated copper indicates there is an oxidative burden on the body
- Ceruloplasmin – When drawn simultaneously with copper, it is useful in determining one’s level of ‘free copper’.
- Zinc, Plasma – Zinc is involved in over 300 metabolic functions of the body. Not least of which is the production of serotonin and dopamine, the removal of copper and the production of ceruloplasmin.
- Vitamin D – Vitamin D status is positively associated with DNA methylation. DNA methylation is a mechanism used by cells to regulate gene expression. Vitamin D3 supplementation increases DNA methylation in a dose-response manner in persons with vitamin D deficiency.
- Homocysteine– Homocysteine is tested with as part of the Walsh Panel in order that therapy for undermethylation does not result in higher levels of homocysteine. It is a marker of cardiovascular inflammation so treatment with methylation supplementation may increase levels and increase risk of cardiovascular incident.
- CBC – CBC includes red blood cell and white blood cell morphology to monitor for infection, anemia, folate/B12 RBC changes and parasite markers
Practitioners who are trained in the Walsh Protocol, in conjunction with a health history and medications review are able better address mood and behavior by correcting particular imbalances. These imbalances influence the activity and performance of neurotransmitters serotonin, dopamine, norepinephrine by causing either an up-regulation or down-regulation of these nerve transmitters. They also reflect whether or not someone is likely experiencing oxidative stress, or epigenetic influence on the DNA’s production of protein. Depression, schizophrenia, autism, biopolar disorders, obsessive compulsive disorders, anxiety and other psychiatric conditions are frequently associated with and imbalance in nutrients that may have an imbalance in one or more of these nutrients or biochemical conditions.