Category Archives: Histamine and Methylation

Treat Elevated Histamine, Naturally

treat elevated histamine naturally

Symptoms of elevated histamine

More and more these days, people suffer from what are simply referred to simply as "allergies." Allergies are reactions by the body to exposure by foods and  other elements that cause the body to release histamine and other biochemical elements such as tryptase, heparin, serotonin and immunoglobulins. The effect of these compounds on the tissues are known as an allergic reaction.

symptoms of mcas mcad high histamine

Treat symptoms of elevated histamine naturally

To treat symptoms of elevated histamine, the best approach is to become familiar with foods and those that contain high levels of histamine or that cause the body to produce high levels of histamine.

High serum levels of histamine lead to common inflammation conditions such as hives, skin rash, diarrhea, runny nose, high stomach acid, nausea, reflux, migraines, irregular menstrual periods, red itchy eyes, etc.

foods high in histamine

Histamine Intolerance and Mast Cell Activation Disorder

Not all histamine reactions are due to allergies. There are a number of conditions that lead to an histamine intolerance. That is true whether the histamines are derived from foods or by our excessive production of, or sensitivity to histamines.

Histamine intolerance, also referred to as histaminosis or HIT or Mast Cell Activation Disorder, may be caused by an increased release or by a lack of histamine degradation enzymes. Histamine intolerance isn't a true allergic reaction. Instead, it refers to a reaction some people experience to foods that have high levels of naturally occurring histamine. The enzymes are required for breaking down ingested or naturally produced histamines.

  • DAO - diamine oxidase. This is the histamine lowering enzyme produced in the intestinal lining and by the kidneys. It circulated through the plasma and serum. Managing histamine intolerance may be addressed by supplementation with enzymes such as DAO
  • HNMT - Histamine N-methyl transferase is a histamine degrading enzyme and it is found within the whole blood cells. Supplements used for symptoms associated with high red blood cell histamine including SAMe and methionine that lower histamine levels.
how SAMe methionine lowers histamine

By treating whole blood histamine with nutrients, serotonin and dopamine levels may be corrected. 

Second Opinion Physician specializes in treating mood disorders and symptoms associated with histamine imbalance within the red blood cells. Because these cells rely on the "methyl" containing enzyme (HNMT), a whole blood histamine level is useful in establishing one's "methylation status." High whole blood histamine indicates undermethylation whereas low blood histamine indicated overmethylation. Presenting his findings at the American Psychiatric Association Conference in 2015, Dr William Walsh, PhD. describes the mood related disorders of high blood histamine and low blood histamine, referring to them as undermethylation and overmethylation respectively.

In managing depression and other symptoms affected by conditions associated with histamine levels we are not specifically treating histamine. We use whole blood histamine blood levels as a measure of over or under methylation status.

Because undermethylators have low functioning levels of serotonin and dopamine, supplementing with methionine and SAMe we can increase the activity of key neurotransmitters. In addition to reducing whole blood levels of histamine, they are important regulators of enzymes involved in serotonin and dopamine reuptake. Overmethylators who, with low whole blood histamine are typically high serotonin depressives. They more frequently benefit from supplements that reduce neurotransmitter activity.

Symptoms of Elevated Whole Blood Histamine

high histamine undermethylation symptoms

Symptoms of Low Whole Blood Histamine

symptoms of low histamine schizophrenia

Test whole blood histamine through this website.

It's a very important test!

Second Opinion Physician offers lab testing for histamine as well as consultations by phone to discuss the results of your lab test. Once ordered you will receive a requisition to take to your nearest Lab Corp.

Related Posts:

Additional Lab Tests for histamine, allergies, MCAS, histaminosis, and methylation:


Biotype Individual Tests

Histamine, Whole Blood


Other Single Item Tests

IgE Immunoglobin E, Total


Bulletproof Radio; Dave Asprey Interviews William Walsh PhD

who is william walsh PhD

  • It’s too late to get healthy once you are already pregnant 00:06:10
  • We can directly affect brain transmitters with nutrients 00:08:00
  • How NAC helps the body and brain 00:10:30
  • We have enough knowledge to use nutrients and diet instead of drugs 00:17:50
  • The ability to edit our genes 00:22:00
  • Nutrients that can cause mischief in the brain 00:47:35
  • The importance of plasma zinc 00:57:00
  • Bigger Ideas:
  • What we can do with diet for young children 00:04:50
  • Why a zero carb diet is not a good idea 00:15:00
  • The next big breakthrough will be preserving the integrity of our DNA 00:19:20
  • Cancer is an event 00:25:00
  • The lay persons’ version of why Bipolar disorder happens 00:35:35
  • How to choose which supplements to take without lab tests 00:54:55

Walsh Protocol Lab Testing

Comprehensive Biotype Panel - The complete set of labs used by Walsh Practitioners for evaluating nutritional biotypes associated with mood disorders.

Consultation with Second Opinion Physician

Complete evaluation of Walsh Panel by our Walsh-trained physician including Biotype Report, detailed supplements plan and discussion regarding test results.

Foods and Supplements that Lower Plasma Histamine Levels

treat elevated histamine naturally

Foods and Antigens that Typically Raise Intestinal and Plasma Histamine

Histamine rich foods: Foods that are associated with high histamine levels include fermented foods such as sauerkraut, kombucha, pickles, wine, yogurt, mature cheeses and fermented soy products. It also includes cured, smoked and fermented meats such as salami and sausage, etc. Tomato paste, spinach and canned fish products also have high histamine levels. Citrus foods are histamine liberators which increase histamine release and so should also be avoided.

Histamine is chemically known as a "biogenic amine". Fermented foods have high levels of these biogenic amines. These are foods that are exposed to microbial decomposition as part of the fermentation or in storage. Lactic acid bacteria are the most problematic biogenic amine producers in fermentation. These bacteria break down amino acids into amine-containing compounds. Biogenic amines are commonly found in wines, cider, dairy, meat, fish, beer, spinach, tomatoes and yeast. Biogenic amines in the form of histamine are the product of bacteria breaking down amino acids. Control biogenic amines to treat elevated histamine

Histamine and Lectins
Foods such as potatoes are high in lectins. Lectins can bind the lining of the intestinal wall and cause leaky gut syndrome. Undigested lectins then enter the blood system and lead to antibody formation and which releases histamine. Foods high in lectins include:

·    White potatoes and unmodified potato starch
·    Tomatoes
·    Soy
·    Gluten containing grains
·    Legumes

Histamine and Probiotics
Probiotics in the digestive tract are responsible for producing many compounds in the body. There are bacterial strains that increase histamine as well as intestinal microbes that reduce histamine.

  • Probiotics that increases histamine
    • Lactobacillus casei
    • Lactobacillus reuteri
    • Lactobacillus bulgaricus

Foods, Supplements and Antigens that Lower Intestinal and Plasma Histamine

Histamine and Mast Cells
Histamine is released from “mast cells”. Mast cells are immune cells that line the mucous membranes of the sinuses, digestive tract, the skin, lungs, eyelids, and tissues surrounding blood vessels and nerves. Activation of mast cells plays a key role in asthma, rhinitis, eczema, itching, pain, autoimmunity and hives. Elevated mast cells are associated with female infertility and decreased sperm motility. Stabilize mast cells to treat elevated histamine.

Histamine INTOLERANCE results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the main enzyme for the metabolism of ingested histamine. It has been proposed that DAO, when functioning as a secretory protein, may be responsible for scavenging extracellular histamine after mediator release. Conversely, histamine N-methyltransferase, the other important enzyme inactivating histamine, is a cytosolic protein that can convert histamine only in the intracellular space of cells. 

Diamine Oxidase DAO
This is an important enzyme that naturally lowers intestinal histamine and extracellular plasma histamine. DAO can be provided as a supplement to lower histamine levels. Symptoms of low DAO includes:

  • Skin irritations - hives, itching, rashes, eczema, psoriasis, and acne
  • Headaches/migraines
  • Painful menstrual periods
  • Gastrointestinal symptoms
  • Intolerance to fermented foods and alcohol
  • Mucous in sinuses
  • Asthma

Other supplements that either contain DAO or improve levels of DAO:

  • White Pea
  • Kidney, Placenta and Liver Glandular Extracts
  • Vitamin C
  • Vitamin B6
  • Pancreatic enzymes
  • Benadryl (works only temporarily, more histamine receptors will likely develop, potentially worsening condition.)

Supplements and OTC medicines that stabilize mast cells

  • Cromalyn sodium (Nasalcrom)
  • Quercitin
  • Curcumin (also decreases DAO)
  • Reishi mushroom
  • Yohimbine
  • Adrenaline
  • Eleuthero
  • Rutin
  • Theanine
  • Astragalus

Probiotics can be used to lower intestinal histamine:

Probiotics in the digestive tract are responsible for producing many compounds in the body. There are bacterial strains that increase histamine as well as intestinal microbes that reduce histamine.

  • Decreases histamine
    • Bifidobacterium infantis
    • Bifidobacterium lognum
    • Lactobacillus plantarum

A list of supplements that may be taken to lower plasma histamine and mast cell expression:

  • DAO diamine oxidase from natural sources (kidney glandular, placenta and White Pea are sources of naturally occuring DAO)
  • Probiotics B infantis, B longum, L plantarum
  • Vitamin C 
  • B6 (can also increase histamine carboxylase)
  • Avoid lectin in diet – potatoes and tomatoes
  • Avoid fermented foods
  • Cromolyn sodium– OTC mast cell stabilizer
  • Benadryl (but it lowers DAO and may ultimately cause increased histamine receptor levels)
  • Bromelain and Quercitin
  • Chocamine  – mast cell stabilizer
  • Improve adrenals with herbal and glandular supplements
  • Curcumin (also decreases DAO)
  • NAC N-acetyl cysteine
  • Catechins (green tea etc)
  • Fatty Acids (long chain and 
  • Micronutrients- Calcium, Iron, Magnesium Zinc, Phosphorus, B12, B6, Vitamin C, 
  • Various glandulars
  • Various herbs
  • White Pea
  • Reishi Mushrooms

Biotype Nutrients is a source for purchasing supplements to manage elevated histamine and MAST Cell disorder. The site offers many top name brands and quality sources.

DISCLAIMER - This is a site developed and owned by Second Opinion Physician for the benefit of persons treating elevated histamine and related conditions.

Tests for evaluating MCAS, Histaminosis, Methylation and Allergies


Biotype Individual Tests

Histamine, Whole Blood


Other Single Item Tests

IgE Immunoglobin E, Total


LDN Low Dose Naltrexone for High Histamine

treat elevated histamine naturally

Low Dose Naltrexone LDN for Symptoms of Histamine Overload

Very low dosages of the pharmaceutical drug naltrexone is being used for histamine intolerance and other inflammatory conditions with great success. It is more commonly recommended in full strength, as an opiate receptor stimulator/blocker for pain syndromes. Because it is a receptor agonist and antagonist, it has a unique characteristic of treating pain without the risk of narcotic overdose. It is also used for treating heroin and other opiate overdoses its receptor antagonist effect allows it to bind some of the opiate receptors sites and block the effects of opiates. As a overdose treatment, most states allow over the pharmacy counter sales for a single, low dose therapy.

Below is a excerpt from a research publication that describes the mechanism of action and treatment benefits of naltrexone.

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
Jarred Younger,corresponding author Luke Parkitny, and David McLain

"Naltrexone, given at low dosages (in the range of 3–5 mg), has been demonstrated to reduce symptom severity in a small number of chronic conditions, including fibromyalgia (1), Crohn's disease (23), multiple sclerosis (45), and pruritus associated with systemic sclerosis (6). The use of naltrexone at this dosage range is typically referred to as low‐dose naltrexone (7). As an orally available compound that is structurally similar to naloxone, naltrexone may work to reduce disease severity by attenuating inflammatory processes (8). This antiinflammatory effect is distinct from the better‐known effect of naltrexone in the blockade of neuronal opioid receptors and may instead involve the antagonism of immune cell receptors, including microglia in the central nervous system (910).

Microglia are the resident macrophages of the central nervous system, and the primary form of immune defense in the brain and spinal cord. The cells normally exist in a resting (ramified) state but are activated by a range of triggers, including cell death, peripheral inflammation, and infection (11). Once activated, microglia undergo drastic morphologic changes and produce proinflammatory factors, such as cytokines, excitatory amino acids, and nitric oxide (12). These inflammatory factors can interact with neurons via multiple channels (13) to cause hyperalgesia, fatigue, and other symptoms (14). The behavioral symptoms of activated microglia (classically called sickness behaviors) are very similar to the primary complaints of fibromyalgia, suggesting that activated microglia may underlie the condition. Fibromyalgia may therefore represent a state of hypersensitive microglial activity and heightened inflammation in the central nervous system. Compounds such as naltrexone, which are known to suppress microglial activity, may therefore be helpful in treating fibromyalgia. By antagonizing microioglial activity (likely via action on Toll‐like receptor 4), naltrexone may suppress the release of proinflammatory factors and thereby reduce pain and other symptoms of fibromyalgia."

Most functnal medicine practitioners are familiar with this LDN low dose naltrexone therapy and prescribe it via a compounding pharmacy. Cost ranges from $75-150 for a prescription. To save costs, some will take a single full strength Naloxone tablet of 50mg and dissolve in water and take 1/30th of this volume on a nightly basis.  This is not recommended as stability and consistency are not predictable. It is advisable to contact your physician for a properly prepared prescription.

Tests available for histamine, immunoglobin, methylation and mast cell evaluation disorder MCAD:


Biotype Individual Tests

Histamine, Whole Blood


Other Single Item Tests

IgE Immunoglobin E, Total